DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis. Strategies & outcomes: Myeloid […]

Evaluating the Efficiency of the Martini Force Field to Study Protein 

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Evaluating the Efficiency of the Martini Force Field to Study Protein Dimerization in Aqueous and Membrane Environments Protein-protein complex assembly is one of the major drivers of biological response. Understanding the mechanisms of protein oligomerization/dimerization would allow one to elucidate how these complexes participate in biological activities and could ultimately lead to new approaches in designing novel […]

Vicilin and legumin storage proteins are abundant

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Vicilin and legumin storage proteins are plentiful in water and alkali soluble protein fractions of glandless cottonseed On this work, we sequentially extracted water (CSPw)- and alkali (CSPa)-soluble protein fractions from glandless cottonseed. SDS-Gel electrophoresis separated CSPw and CSPa to eight and 14 dominant polypeptide bands (110-10 kDa), respectively. Liquid chromatography-electrospray ionization-tandem mass spectrometry recognized peptide fragments from 336 […]

Statistical Equivalence Testing of Higher-Order Protein Structures

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Statistical Equivalence Testing of Greater-Order Protein Buildings with Differential Hydrogen Trade-Mass Spectrometry (HX-MS) Hydrogen exchange-mass spectrometry (HX-MS) is well known for its potential utility for establishing the equivalence of the higher-order constructions of proteins, notably in comparability and similarity contexts. Nevertheless, current progress within the statistical evaluation of HX-MS information has as an alternative positioned an emphasis […]