Adsorbed Protein Movie on Pump Surfaces Results in Particle Formation Throughout Fill-End Manufacturing Throughout fill-finish manufacturing, therapeutic proteins might mixture or type subvisible particles in response to the bodily stresses encountered inside filling pumps. Understanding and quantitating this threat is necessary since filling could be the final unit operation earlier than the affected person receives their dose. […]
DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS
DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis. Strategies & outcomes: Myeloid […]
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