DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown

Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis.

Strategies & outcomes: Myeloid particular PHD knockout (PHDko) mice had been obtained through bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown by means of lysozyme M-driven Cre recombinase (PHD2cko). Mice had been fed excessive ldl cholesterol eating regimen for 6-12 weeks to induce atherosclerosis. Aortic root plaque measurement was considerably augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko in comparison with controls, however was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, through the HIF1α/BNIP3 axis. Bulk and single cell RNA knowledge of PHD2cko bone-marrow-derived macrophages (BMDM) and plaque macrophages, respectively, confirmed enhanced HIF1α/BNIP3 signaling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively related to plaque necrotic core measurement, suggesting comparable pro-apoptotic results in human.

Additional, PHD2cko plaques displayed enhanced fibrosis, whereas macrophage collagen breakdown by matrix metalloproteinases, collagen manufacturing and proliferation had been unaltered. As an alternative, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine method. In silico evaluation of macrophage-fibroblast communication predicted SPP1 (osteopontin) signaling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Elevated SPP1 mRNA expression upon PHD2cko was preferentially noticed in foamy plaque macrophages expressing “triggering receptor expressed on myeloid cells-2” (TREM2hi) evidenced by single-cell RNA, however not in neutrophils. This confirmed enhanced fibrotic signaling by PHD2cko macrophages to fibroblasts, in vitro in addition to in vivo.

Conclusion: Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque progress and macrophage apoptosis, whereas PHD2cko macrophages additional activated collagen secretion by fibroblasts in vitro, possible through paracrine SPP1 signaling by means of TREM2hi macrophages.

Translational outlook: This research exhibits that myeloid PHD isoforms PHD2 and PHD3 worsen plaque traits and phenotype, corresponding to plaque measurement, macrophage accumulation, apoptosis, and collagen accumulation in mice. We present each direct results on macrophages and paracrine results of macrophage PHD2 loss on vessel wall fibroblast populations. Broad spectrum-PHD inhibitors, e.g. Roxadustat, are presently being prescribed to power kidney illness sufferers, who’re already in danger for heart problems. When contemplating this research and the pro-fibrotic and pro-apoptotic results we report, broad PHD inhibition might due to this fact be sub-optimal and extra focused PHD inhibition of PHD1 must be thought of.

The results of various temperatures of post-exercise protein-containing drink on gastric motility and power consumption in wholesome younger males 

The current research examined the consequences of various temperatures of protein-containing drink after train on subsequent gastric motility and power consumption in wholesome younger males. Twelve wholesome younger males accomplished three, one-day trials in a random order. In all trials, the topics ran on a treadmill for 30 min at 80% of most coronary heart fee. In train + chilly drink (2 °C) and train + sizzling drink (60 °C) trials, the topics consumed 300 mL of protein-containing drink (0.34 MJ) at 2 °C or 60 °C over a 5-min interval after train. Within the train (i.e., no preload) trial, the topics sat on a chair for five min after train. Then, the topics sat on a chair for 30 min to measure their gastric motility with an ultrasound imaging system in all trials.

Thereafter, the topics consumed a take a look at meal till they felt comfortably full. Vitality consumption within the train + sizzling drink trial was 14 % and 15 % greater than the train (P=0.046, 95% CI: 4.010-482.538) trial and train + chilly drink (P=0.001, 95% CI: 160.089-517.111) trial, respectively. The frequency of the gastric contractions within the train + sizzling drink trial was greater than the train (P=0.023) trial and train + chilly drink (P=0.007) trial. The overall frequency of gastric contractions was positively associated to power consumption (r=0.386, P=0.022). These findings reveal that consuming protein-containing drink after train at 60 °C will increase power consumption and that this improve could also be associated to the modulation of the gastric motility.

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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

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Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

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  • 1 plate of 96 wells
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Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody(IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

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YF-PA24148 50 ul
EUR 334
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Description: Mouse polyclonal to Human Milk Fat Globule 1

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YF-PA13136 100 ul
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

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Polyclonal Goat anti-GST α-form

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EUR 439

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FNab02360 100µg
EUR 585
Description: Antibody raised against DGKK-Specific

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FNab02415 100µg
EUR 585
Description: Antibody raised against DLL1-Specific

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FNab02493 100µg
EUR 505.25
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FNab02530 100µg
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FNab02801 100µg
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FNab02804 100µg
EUR 505.25
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FNab02937 100µg
EUR 585
Description: Antibody raised against FABP7-Specific

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FNab03004 100µg
EUR 585
Description: Antibody raised against FANCA-Specific

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FNab03276 100µg
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FNab03278 100µg
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FNab03290 100µg
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FNab03363 100µg
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FNab03416 100µg
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Description: Antibody raised against GEFT-Specific

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FNab03477 100µg
EUR 505.25
Description: Antibody raised against GLI2-Specific

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FNab03478 100µg
EUR 505.25
Description: Antibody raised against GLI3-Specific

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FNab03587 100µg
EUR 585
Description: Antibody raised against GPR101-Specific

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FNab03592 100µg
EUR 585
Description: Antibody raised against GPR123-Specific

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FNab03596 100µg
EUR 505.25
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FNab03612 100µg
EUR 585
Description: Antibody raised against GPRASP1-Specific

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FNab03616 100µg
EUR 548.75
Description: Antibody raised against GPRIN3-Specific

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FNab03767 100µg
EUR 585
Description: Antibody raised against HBA1-Specific

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FNab03772 100µg
EUR 585
Description: Antibody raised against HBG1-Specific

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FNab03773 100µg
EUR 585
Description: Antibody raised against HBM-Specific

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FNab03776 100µg
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Description: Antibody raised against HBQ1-Specific

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FNab03780 100µg
EUR 585
Description: Antibody raised against HBZ-Specific

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FNab03795 100µg
EUR 505.25
Description: Antibody raised against HDAC1-specific

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FNab03797 100µg
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Description: Antibody raised against HDAC2-specific

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FNab03799 100µg
EUR 548.75
Description: Antibody raised against HDAC3-specific

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FNab03801 100µg
EUR 505.25
Description: Antibody raised against HDAC4-specific

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FNab03802 100µg
EUR 585
Description: Antibody raised against HDAC5-specific

anti- HDAC6-specific antibody

FNab03804 100µg
EUR 505.25
Description: Antibody raised against HDAC6-specific

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FNab03870 100µg
EUR 548.75
Description: Antibody raised against HIP1-Specific

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FNab03936 100µg
EUR 505.25
Description: Antibody raised against HMMR-Specific

anti- HNRNPUL2-Specific antibody

FNab03961 100µg
EUR 585
Description: Antibody raised against HNRNPUL2-Specific

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FNab04008 100µg
EUR 585
Description: Antibody raised against HRAS-Specific

anti- HSPG2-Specific antibody

FNab04063 100µg
EUR 548.75
Description: Antibody raised against HSPG2-Specific

anti- IFITM1-Specific antibody

FNab04141 100µg
EUR 585
Description: Antibody raised against IFITM1-Specific

anti- IFITM2-specific antibody

FNab04143 100µg
EUR 585
Description: Antibody raised against IFITM2-specific

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EUR 548.75
Description: Antibody raised against IGF1B-Specific

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FNab04174 100µg
EUR 585
Description: Antibody raised against IGF2R-Specific

anti- ING1-specific antibody

FNab04309 100µg
EUR 548.75
Description: Antibody raised against ING1-specific

anti- ING3-specific antibody

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EUR 548.75
Description: Antibody raised against ING3-specific

anti- ING4-specific antibody

FNab04314 100µg
EUR 505.25
Description: Antibody raised against ING4-specific

Induction of protecting immune responses in opposition to a deadly Zika virus problem post-vaccination with a twin serotype of recombinant vesicular stomatitis virus carrying the genetically modified Zika virus E protein gene

The event of a vaccine to forestall Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine in opposition to ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. We’ve employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a kind 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.

Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced robust protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.

Chilly-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β manufacturing 

Background: Gout is an autoinflammatory illness pushed by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β manufacturing relies on inflammasome activation, which requires a priming sign, adopted by an activating sign. The cold-inducible RNA-binding protein (CIRP) has been not too long ago recognized as a damage-associated molecular sample (DAMP). On this research, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1β secretion utilizing human neutrophils. 

Strategies: Human neutrophils had been stimulated by MSU within the presence or absence of CIRP priming to find out NLRP3 inflammasome activation and subsequent caspase-1 activation and IL-1β manufacturing. Mobile supernatants had been analyzed by enzyme-linked immunosorbent assay (ELISA) to find out the presence of IL-1β or caspase-1 (p20). The mobile supernatants and lysates had been additionally analyzed by immunoblotting utilizing anti-cleaved IL-1β or anti-cleaved caspase-1 antibodies.

Outcomes: Neither CIRP nor MSU stimulation alone induced ample IL-1β secretion from neutrophils. Nevertheless, MSU stimulation induced IL-1β secretion from CIRP-primed neutrophils in a dose-dependent method. This MSU-induced IL-1β secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1β (p17), which was inhibited by the pretreatment of MCC950, a selected inhibitor for NLRP3. Moreover, cleaved caspase-1 was induced within the mobile lysates of CIRP/MSU-treated neutrophils. Moreover, CIRP stimulation induced the protein expression of pro-IL-1β in neutrophils. 

Conclusions: Our knowledge point out that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1β induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. We suggest that CIRP acts as an necessary proinflammatory stimulant that primes and prompts inflammasome and pro-IL-1β processing in response to uric acid in innate immune cells.

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7618-1000
EUR 4345

HDAC-8, human recombinant

7618-20
EUR 262

CST3 Mouse, Cystatin-C, Recombinant Protein Mouse Active

PROTP21460-3 Regular: 10ug
EUR 317
Description: CST3 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140 a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

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HY-19772 50mg
EUR 2116

HDAC 3 antibody

20R-1663 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 3 antibody

NCOR2/ Rat NCOR2 ELISA Kit

ELA-E11288r 96 Tests
EUR 886

HDAC-3 Blocking Peptide

3603BP-50
EUR 153

HDAC 3 Blocking Peptide

33R-10518 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 3 antibody, catalog no. 20R-1663

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

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20-abx925532
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

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20-abx925533
  • EUR 551.00
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  • 15 nmol
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1-CSB-PA080039
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

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1-CSB-PA015548GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NCOR2 Antibody

43109-100ul 100ul
EUR 252

NCOR2 Antibody

DF8896 200ul
EUR 304
Description: NCOR2 Antibody detects endogenous levels of total NCOR2.

NCOR2 Antibody

ABD8896 100 ug
EUR 438

anti-NCOR2

YF-PA25381 50 ul
EUR 334
Description: Mouse polyclonal to NCOR2

NCOR2 antibody

PAab10069 100 ug
EUR 386

NCOR2 antibody

70R-18789 50 ul
EUR 435
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 antibody

70R-32241 100 ug
EUR 327
Description: Rabbit polyclonal NCOR2 antibody

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EUR 689

Human NCOR2 shRNA Plasmid

20-abx956396
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
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NCOR2 ELISA KIT|Human

EF000574 96 Tests
EUR 689

Human NCOR2 ELISA Kit

ELA-E0334h 96 Tests
EUR 824

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

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4865-10
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PRMT1, human recombinant (Active)

4865-1000
EUR 3834

PRMT1, human recombinant (Active)

4865-50
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Active AHCY, human recombinant

7527-10
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Active AHCY, human recombinant

7527-1000
EUR 5482

Active AHCY, human recombinant

7527-50
EUR 479

Active Recombinant Human CETP

7606-100
EUR 805

Active Recombinant Human CETP

7606-1000
EUR 4345

Active Recombinant Human CETP

7606-20
EUR 262

Active SIRT2, human recombinant

7698-10
EUR 262

Active SIRT2, human recombinant

7698-1000
EUR 4394

Active SIRT2, human recombinant

7698-50
EUR 457

Active SIRT7, human recombinant

7846-10
EUR 218

Active SIRT7, human recombinant

7846-50
EUR 588

Irisin, Active, human recombinant

7852-10
EUR 370

Irisin, Active, human recombinant

7852-50
EUR 1077

HER2, Active, Human Recombinant

8011-5
EUR 240

HER2, Active, Human Recombinant

8011-50
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GAPDH, Active, human recombinant

P1100-10
EUR 142

GAPDH, Active, human recombinant

P1100-50
EUR 392

NCOR2 sgRNA CRISPR Lentivector (Human) (Target 3)

K1400604 1.0 ug DNA
EUR 154

HDAC-IN-7

HY-13592 10mM/1mL
EUR 215

Apicidin (HDAC inhibitor)

SIH-346-1MG 1 mg
EUR 136
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

Apicidin (HDAC inhibitor)

SIH-346-5MG 5 mg
EUR 340
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

HPA (HDAC inhibitor)

SIH-356-10MG 10 mg
EUR 128
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HPA (HDAC inhibitor)

SIH-356-50MG 50 mg
EUR 226
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HDAC Set I

A9906-1 1 Set
EUR 154

HDAC Substrate, Colorimetric

2207-100
EUR 300

HDAC Substrate, Colorimetric

2207-25
EUR 126

HDAC Substrate, Fluorogenic

2396-25
EUR 512

HDAC Substrate, Fluorogenic

2396-5
EUR 175

HDAC 6 antibody

20R-1667 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 6 antibody

HDAC 7 antibody

20R-1668 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 7 antibody

HDAC 8 antibody

20R-1669 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 8 antibody

HDAC 9 antibody

20R-1670 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 9 antibody

HDAC 10 antibody

20R-1671 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 10 antibody

HDAC 11 antibody

20R-1672 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 11 antibody

HDAC 1 antibody

20R-1661 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 1 antibody

HDAC 2 antibody

20R-1662 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 2 antibody

HDAC 4 antibody

20R-1664 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 4 antibody

20R-1665 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 5 antibody

20R-1666 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 5 antibody

HDAC Assay Kit

55R-1371 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit

55R-1372 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

Anti-NCOR2 antibody

STJ110686 100 µl
EUR 277
Description: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

NCOR2 Rabbit pAb

A8388-100ul 100 ul
EUR 308

NCOR2 Rabbit pAb

A8388-200ul 200 ul
EUR 459

NCOR2 Rabbit pAb

A8388-20ul 20 ul
EUR 183

NCOR2 Rabbit pAb

A8388-50ul 50 ul
EUR 223

anti- NCOR2 antibody

FNab05594 100µg
EUR 505.25
Description: Antibody raised against NCOR2

anti- NCOR2 antibody

FNab10069 100µg
EUR 548.75
Description: Antibody raised against NCOR2

NCOR2 Conjugated Antibody

C43109 100ul
EUR 397

NCOR2 Blocking Peptide

DF8896-BP 1mg
EUR 195

Anti-NCOR2 antibody

PAab05594 100 ug
EUR 355

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

NCOR2 ELISA Kit (Human) (OKEH04298)

OKEH04298 96 Wells
EUR 662
Description: Description of target: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 100 pg/mL

NCOR2 ORF Vector (Human) (pORF)

ORF025977 1.0 ug DNA
EUR 2730

Recombinant Human Activin-A Active

7-00004 1ug Ask for price

Recombinant Human Activin-A Active

7-00005 5ug Ask for price

Recombinant Human Activin-A Active

7-00006 100µg Ask for price

Recombinant Human Activin-B Active

7-00010 1ug Ask for price

Recombinant Human Activin-B Active

7-00011 5ug Ask for price

Recombinant Human Activin-B Active

7-00012 100µg Ask for price

Active Cathepsin S, human recombinant

7526-10
EUR 338

Active Cathepsin S, human recombinant

7526-50
EUR 1126

Active Cathepsin S, human recombinant

7526-500
EUR 9130

Active Cathepsin B, human recombinant

7580-1000
EUR 9783

Active Cathepsin B, human recombinant

7580-5
EUR 294

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