DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

0 Comments
pharmasquare

DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown

Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis.

Strategies & outcomes: Myeloid particular PHD knockout (PHDko) mice had been obtained through bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown by means of lysozyme M-driven Cre recombinase (PHD2cko). Mice had been fed excessive ldl cholesterol eating regimen for 6-12 weeks to induce atherosclerosis. Aortic root plaque measurement was considerably augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko in comparison with controls, however was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, through the HIF1α/BNIP3 axis. Bulk and single cell RNA knowledge of PHD2cko bone-marrow-derived macrophages (BMDM) and plaque macrophages, respectively, confirmed enhanced HIF1α/BNIP3 signaling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively related to plaque necrotic core measurement, suggesting comparable pro-apoptotic results in human.

Additional, PHD2cko plaques displayed enhanced fibrosis, whereas macrophage collagen breakdown by matrix metalloproteinases, collagen manufacturing and proliferation had been unaltered. As an alternative, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine method. In silico evaluation of macrophage-fibroblast communication predicted SPP1 (osteopontin) signaling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Elevated SPP1 mRNA expression upon PHD2cko was preferentially noticed in foamy plaque macrophages expressing “triggering receptor expressed on myeloid cells-2” (TREM2hi) evidenced by single-cell RNA, however not in neutrophils. This confirmed enhanced fibrotic signaling by PHD2cko macrophages to fibroblasts, in vitro in addition to in vivo.

Conclusion: Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque progress and macrophage apoptosis, whereas PHD2cko macrophages additional activated collagen secretion by fibroblasts in vitro, possible through paracrine SPP1 signaling by means of TREM2hi macrophages.

Translational outlook: This research exhibits that myeloid PHD isoforms PHD2 and PHD3 worsen plaque traits and phenotype, corresponding to plaque measurement, macrophage accumulation, apoptosis, and collagen accumulation in mice. We present each direct results on macrophages and paracrine results of macrophage PHD2 loss on vessel wall fibroblast populations. Broad spectrum-PHD inhibitors, e.g. Roxadustat, are presently being prescribed to power kidney illness sufferers, who’re already in danger for heart problems. When contemplating this research and the pro-fibrotic and pro-apoptotic results we report, broad PHD inhibition might due to this fact be sub-optimal and extra focused PHD inhibition of PHD1 must be thought of.

The results of various temperatures of post-exercise protein-containing drink on gastric motility and power consumption in wholesome younger males 

The current research examined the consequences of various temperatures of protein-containing drink after train on subsequent gastric motility and power consumption in wholesome younger males. Twelve wholesome younger males accomplished three, one-day trials in a random order. In all trials, the topics ran on a treadmill for 30 min at 80% of most coronary heart fee. In train + chilly drink (2 °C) and train + sizzling drink (60 °C) trials, the topics consumed 300 mL of protein-containing drink (0.34 MJ) at 2 °C or 60 °C over a 5-min interval after train. Within the train (i.e., no preload) trial, the topics sat on a chair for five min after train. Then, the topics sat on a chair for 30 min to measure their gastric motility with an ultrasound imaging system in all trials.

Thereafter, the topics consumed a take a look at meal till they felt comfortably full. Vitality consumption within the train + sizzling drink trial was 14 % and 15 % greater than the train (P=0.046, 95% CI: 4.010-482.538) trial and train + chilly drink (P=0.001, 95% CI: 160.089-517.111) trial, respectively. The frequency of the gastric contractions within the train + sizzling drink trial was greater than the train (P=0.023) trial and train + chilly drink (P=0.007) trial. The overall frequency of gastric contractions was positively associated to power consumption (r=0.386, P=0.022). These findings reveal that consuming protein-containing drink after train at 60 °C will increase power consumption and that this improve could also be associated to the modulation of the gastric motility.

pharmasquare
pharmasquare

Anti-Total Goat Milk Proteins

4042-PA 1 ml
EUR 488
Description: Anti-Total Goat Milk Proteins by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A 1000 ml
EUR 565
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-100 100 ml
EUR 257
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-500 500 ml
EUR 411
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Antigen Concentrate

F243H 100 ul
EUR 411
Description: Goat Milk Proteins Antigen Concentrate by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Control Antigen

F247 50 ul
EUR 257
Description: Goat Milk Proteins Control Antigen by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins ELISA kit

F240 1 kit (96 wells plate)
EUR 1080
Description: Total Goat Milk Proteins ELISA kit by Cygnus Technologies is available in Europe via Gentaur.

Total Goat Milk Proteins WB kit

F245 1 kit (application dependant amount of reactions)
EUR 836
Description: Total Goat Milk Proteins WB kit by Cygnus Technologies is available in Europe via Gentaur.

Rabbit Polyclonal antibody Anti-CRBN

Anti-CRBN 50 µg
EUR 349

Anti-milk fat globulin antibody

STJ16100177 100 µg
EUR 406

Human milk specific allergen antibody(IgE) ELISA Kit

CSB-E15859h-24T 1 plate of 24 wells
EUR 165
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody (IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. A new trial version of the kit, which allows you to test the kit in your application at a reasonable price.

Human milk specific allergen antibody(IgE) ELISA Kit

1-CSB-E15859h
  • EUR 804.00
  • EUR 5099.00
  • EUR 2704.00
  • 1 plate of 96 wells
  • 10 plates of 96 wells each
  • 5 plates of 96 wells each
Description: Quantitativesandwich ELISA kit for measuring Human milk specific allergen antibody(IgE) in samples from serum, plasma, cell culture supernates, tissue homogenates. Now available in a cost efficient pack of 5 plates of 96 wells each, conveniently packed along with the other reagents in 5 separate kits.

Anti-Goat Milk Proteins:HRP Conjugate

F241 12 ml
EUR 488
Description: Anti-Goat Milk Proteins:HRP Conjugate by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04 1 ml
EUR 334
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-AF 1 mg
EUR 1913
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04-PA 1 ml
EUR 488
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Anti-Bovine Plasma Proteins

BPP04AF-HRP 100 ul
EUR 989
Description: Anti-Bovine Plasma Proteins by Cygnus Technologies is available in Europe via Gentaur.

Skim Milk

abx082021-100g 100 g
EUR 217

anti-Human Milk Fat Globule 1

YF-PA13135 50 ug
EUR 363
Description: Mouse polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13136 100 ul
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA13137 100 ug
EUR 403
Description: Rabbit polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1

YF-PA24148 50 ul
EUR 334
Description: Mouse polyclonal to Human Milk Fat Globule 1

Polyclonal Goat anti-GST α-form

GST-ANTI-1 50 uL
EUR 280

Polyclonal Goat anti-GST μ-form

GST-ANTI-2 50 uL
EUR 280

Polyclonal Goat anti-GST p-form

GST-ANTI-3 50 uL
EUR 280

Anti-Human Milk Fat Globule 1/MFGE8 Antibody

PA1945 100ug/vial
EUR 334

Lys proteins Antibody

abx219526-100ug 100 ug
EUR 439

Lys proteins Antibody

DF2705 200ul
EUR 304
Description: Lys proteins antibody detects endogenous levels of total Lys proteins.

Lys proteins Antibody

ABD2705 100 ug
EUR 438

anti- BLOC1S1-Specific antibody

FNab00909 100µg
EUR 505.25
Description: Antibody raised against BLOC1S1-Specific

anti- BRN2-Specific antibody

FNab00963 100µg
EUR 505.25
Description: Antibody raised against BRN2-Specific

anti- CAPG-Specific antibody

FNab01249 100µg
EUR 505.25
Description: Antibody raised against CAPG-Specific

anti- Catalase-Specific antibody

FNab01302 100µg
EUR 505.25
Description: Antibody raised against Catalase-Specific

anti- CCKAR-specific antibody

FNab01377 100µg
EUR 505.25
Description: Antibody raised against CCKAR-specific

anti- CCKBR-specific antibody

FNab01378 100µg
EUR 505.25
Description: Antibody raised against CCKBR-specific

anti- CCR2-specific antibody

FNab01390 100µg
EUR 505.25
Description: Antibody raised against CCR2-specific

anti- CCT6A-Specific antibody

FNab01401 100µg
EUR 505.25
Description: Antibody raised against CCT6A-Specific

anti- CDH10-specific antibody

FNab01546 100µg
EUR 505.25
Description: Antibody raised against CDH10-specific

anti- CDK1-Specific antibody

FNab01552 100µg
EUR 505.25
Description: Antibody raised against CDK1-Specific

anti- CEACAM3-Specific antibody

FNab01578 100µg
EUR 505.25
Description: Antibody raised against CEACAM3-Specific

anti- CEP350-Specific antibody

FNab01603 100µg
EUR 505.25
Description: Antibody raised against CEP350-Specific

anti- CES7-Specific antibody

FNab01618 100µg
EUR 505.25
Description: Antibody raised against CES7-Specific

anti- CHST13-Specific antibody

FNab01693 100µg
EUR 548.75
Description: Antibody raised against CHST13-Specific

anti- CISD2-Specific antibody

FNab01719 100µg
EUR 505.25
Description: Antibody raised against CISD2-Specific

anti- CPNE9-Specific antibody

FNab01932 100µg
EUR 505.25
Description: Antibody raised against CPNE9-Specific

anti- CPT1B-specific antibody

FNab01944 100µg
EUR 548.75
Description: Antibody raised against CPT1B-specific

anti- CPT1C-specific antibody

FNab01946 100µg
EUR 505.25
Description: Antibody raised against CPT1C-specific

anti- CRLS1-Specific antibody

FNab01983 100µg
EUR 548.75
Description: Antibody raised against CRLS1-Specific

anti- CST2-Specific antibody

FNab02033 100µg
EUR 505.25
Description: Antibody raised against CST2-Specific

anti- CSTL1-Specific antibody

FNab02041 100µg
EUR 505.25
Description: Antibody raised against CSTL1-Specific

anti- CUL4A-Specific antibody

FNab02078 100µg
EUR 505.25
Description: Antibody raised against CUL4A-Specific

anti- CXCR3B-specific antibody

FNab02101 100µg
EUR 505.25
Description: Antibody raised against CXCR3B-specific

anti- CXCR7-Specific antibody

FNab02107 100µg
EUR 548.75
Description: Antibody raised against CXCR7-Specific

anti- CYP1A2-Specific antibody

FNab02148 100µg
EUR 505.25
Description: Antibody raised against CYP1A2-Specific

anti- CYP2E1-Specific antibody

FNab02159 100µg
EUR 505.25
Description: Antibody raised against CYP2E1-Specific

anti- CYP4F11-Specific antibody

FNab02171 100µg
EUR 505.25
Description: Antibody raised against CYP4F11-Specific

anti- CYP4Z1-Specific antibody

FNab02175 100µg
EUR 505.25
Description: Antibody raised against CYP4Z1-Specific

anti- DAPK2-Specific antibody

FNab02241 100µg
EUR 548.75
Description: Antibody raised against DAPK2-Specific

anti- DCC-Specific antibody

FNab02262 100µg
EUR 505.25
Description: Antibody raised against DCC-Specific

anti- DGKK-Specific antibody

FNab02360 100µg
EUR 585
Description: Antibody raised against DGKK-Specific

anti- DLL1-Specific antibody

FNab02415 100µg
EUR 585
Description: Antibody raised against DLL1-Specific

anti- DOCK180-Specific antibody

FNab02493 100µg
EUR 505.25
Description: Antibody raised against DOCK180-Specific

anti- DR5-Specific antibody

FNab02530 100µg
EUR 585
Description: Antibody raised against DR5-Specific

anti- EDG7-Specific antibody

FNab02635 100µg
EUR 505.25
Description: Antibody raised against EDG7-Specific

anti- EGFR-Specific antibody

FNab02669 100µg
EUR 505.25
Description: Antibody raised against EGFR-Specific

anti- EIF2C1-Specific antibody

FNab02697 100µg
EUR 505.25
Description: Antibody raised against EIF2C1-Specific

anti- EIF2C3-Specific antibody

FNab02698 100µg
EUR 505.25
Description: Antibody raised against EIF2C3-Specific

anti- EPHA1-specific antibody

FNab02801 100µg
EUR 548.75
Description: Antibody raised against EPHA1-specific

anti- EPHA6-Specific antibody

FNab02804 100µg
EUR 505.25
Description: Antibody raised against EPHA6-Specific

anti- FABP7-Specific antibody

FNab02937 100µg
EUR 585
Description: Antibody raised against FABP7-Specific

anti- FANCA-Specific antibody

FNab03004 100µg
EUR 585
Description: Antibody raised against FANCA-Specific

anti- FcRn-Specific antibody

FNab03063 100µg
EUR 585
Description: Antibody raised against FcRn-Specific

anti- FGF16-Specific antibody

FNab03091 100µg
EUR 505.25
Description: Antibody raised against FGF16-Specific

anti- FMO2-specific antibody

FNab03169 100µg
EUR 548.75
Description: Antibody raised against FMO2-specific

anti- FMO5-specific antibody

FNab03171 100µg
EUR 548.75
Description: Antibody raised against FMO5-specific

anti- FOXH1-Specific antibody

FNab03196 100µg
EUR 548.75
Description: Antibody raised against FOXH1-Specific

anti- FOXL2-Specific antibody

FNab03199 100µg
EUR 505.25
Description: Antibody raised against FOXL2-Specific

anti- GAB3-Specific antibody

FNab03273 100µg
EUR 505.25
Description: Antibody raised against GAB3-Specific

anti- GABARAPL1-Specific antibody

FNab03276 100µg
EUR 505.25
Description: Antibody raised against GABARAPL1-Specific

anti- GABARAPL2-Specific antibody

FNab03278 100µg
EUR 505.25
Description: Antibody raised against GABARAPL2-Specific

anti- GAC-specific antibody

FNab03290 100µg
EUR 505.25
Description: Antibody raised against GAC-specific

anti- GATA4-Specific antibody

FNab03363 100µg
EUR 505.25
Description: Antibody raised against GATA4-Specific

anti- GEFT-Specific antibody

FNab03416 100µg
EUR 548.75
Description: Antibody raised against GEFT-Specific

anti- GLI2-Specific antibody

FNab03477 100µg
EUR 505.25
Description: Antibody raised against GLI2-Specific

anti- GLI3-Specific antibody

FNab03478 100µg
EUR 505.25
Description: Antibody raised against GLI3-Specific

anti- GPR101-Specific antibody

FNab03587 100µg
EUR 585
Description: Antibody raised against GPR101-Specific

anti- GPR123-Specific antibody

FNab03592 100µg
EUR 585
Description: Antibody raised against GPR123-Specific

anti- GPR139-Specific antibody

FNab03596 100µg
EUR 505.25
Description: Antibody raised against GPR139-Specific

anti- GPRASP1-Specific antibody

FNab03612 100µg
EUR 585
Description: Antibody raised against GPRASP1-Specific

anti- GPRIN3-Specific antibody

FNab03616 100µg
EUR 548.75
Description: Antibody raised against GPRIN3-Specific

anti- HBA1-Specific antibody

FNab03767 100µg
EUR 585
Description: Antibody raised against HBA1-Specific

anti- HBG1-Specific antibody

FNab03772 100µg
EUR 585
Description: Antibody raised against HBG1-Specific

anti- HBM-Specific antibody

FNab03773 100µg
EUR 585
Description: Antibody raised against HBM-Specific

anti- HBQ1-Specific antibody

FNab03776 100µg
EUR 585
Description: Antibody raised against HBQ1-Specific

anti- HBZ-Specific antibody

FNab03780 100µg
EUR 585
Description: Antibody raised against HBZ-Specific

anti- HDAC1-specific antibody

FNab03795 100µg
EUR 505.25
Description: Antibody raised against HDAC1-specific

anti- HDAC2-specific antibody

FNab03797 100µg
EUR 505.25
Description: Antibody raised against HDAC2-specific

anti- HDAC3-specific antibody

FNab03799 100µg
EUR 548.75
Description: Antibody raised against HDAC3-specific

anti- HDAC4-specific antibody

FNab03801 100µg
EUR 505.25
Description: Antibody raised against HDAC4-specific

anti- HDAC5-specific antibody

FNab03802 100µg
EUR 585
Description: Antibody raised against HDAC5-specific

anti- HDAC6-specific antibody

FNab03804 100µg
EUR 505.25
Description: Antibody raised against HDAC6-specific

anti- ACADL-Specific antibody

FNab00064 100µg
EUR 505.25
Description: Antibody raised against ACADL-Specific

anti- ACTA1-Specific antibody

FNab00115 100µg
EUR 505.25
Description: Antibody raised against ACTA1-Specific

anti- ADAM17-Specific antibody

FNab00139 100µg
EUR 505.25
Description: Antibody raised against ADAM17-Specific

anti- ADRA1A-Specific antibody

FNab00177 100µg
EUR 505.25
Description: Antibody raised against ADRA1A-Specific

anti- ADRA2B-Specific antibody

FNab00179 100µg
EUR 548.75
Description: Antibody raised against ADRA2B-Specific

anti- AFF1-Specific antibody

FNab00195 100µg
EUR 505.25
Description: Antibody raised against AFF1-Specific

anti- AMPD1-Specific antibody

FNab00370 100µg
EUR 548.75
Description: Antibody raised against AMPD1-Specific

anti- ARF5-Specific antibody

FNab00534 100µg
EUR 505.25
Description: Antibody raised against ARF5-Specific

anti- ARF6-Specific antibody

FNab00535 100µg
EUR 505.25
Description: Antibody raised against ARF6-Specific

anti- ARHGEF9-Specific antibody

FNab00565 100µg
EUR 505.25
Description: Antibody raised against ARHGEF9-Specific

anti- ARSK-Specific antibody

FNab00613 100µg
EUR 505.25
Description: Antibody raised against ARSK-Specific

anti- ATF2-Specific antibody

FNab00661 100µg
EUR 505.25
Description: Antibody raised against ATF2-Specific

anti- ATP1A1-Specific antibody

FNab00692 100µg
EUR 548.75
Description: Antibody raised against ATP1A1-Specific

anti- ATP1A2-Specific antibody

FNab00694 100µg
EUR 548.75
Description: Antibody raised against ATP1A2-Specific

anti- ATP5G2-Specific antibody

FNab00708 100µg
EUR 505.25
Description: Antibody raised against ATP5G2-Specific

anti- BAG1S-specific antibody

FNab00788 100µg
EUR 548.75
Description: Antibody raised against BAG1S-specific

anti- BAI2-Specific antibody

FNab00791 100µg
EUR 505.25
Description: Antibody raised against BAI2-Specific

anti- BAI3-Specific antibody

FNab00792 100µg
EUR 505.25
Description: Antibody raised against BAI3-Specific

anti- Barkor-Specific antibody

FNab00806 100µg
EUR 505.25
Description: Antibody raised against Barkor-Specific

anti- PACS2-Specific antibody

FNab06099 100µg
EUR 505.25
Description: Antibody raised against PACS2-Specific

anti- Palladin-Specific antibody

FNab06127 100µg
EUR 585
Description: Antibody raised against Palladin-Specific

anti- PAX1-Specific antibody

FNab06167 100µg
EUR 548.75
Description: Antibody raised against PAX1-Specific

anti- PAX8-Specific antibody

FNab06177 100µg
EUR 585
Description: Antibody raised against PAX8-Specific

anti- persephin-Specific antibody

FNab06323 100µg
EUR 585
Description: Antibody raised against persephin-Specific

anti- PFKFB3-Specific antibody

FNab06339 100µg
EUR 505.25
Description: Antibody raised against PFKFB3-Specific

anti- PKM1-specific antibody

FNab06494 100µg
EUR 548.75
Description: Antibody raised against PKM1-specific

anti- PKM2-specific antibody

FNab06495 100µg
EUR 548.75
Description: Antibody raised against PKM2-specific

anti- PKM2-specific antibody

FNab06496 100µg
EUR 548.75
Description: Antibody raised against PKM2-specific

anti- PLOD2-Specific antibody

FNab06552 100µg
EUR 505.25
Description: Antibody raised against PLOD2-Specific

anti- POLR2B-Specific antibody

FNab06620 100µg
EUR 505.25
Description: Antibody raised against POLR2B-Specific

anti- POTEA-Specific antibody

FNab06647 100µg
EUR 585
Description: Antibody raised against POTEA-Specific

anti- POTED-Specific antibody

FNab06648 100µg
EUR 585
Description: Antibody raised against POTED-Specific

anti- POU3F3-Specific antibody

FNab06651 100µg
EUR 505.25
Description: Antibody raised against POU3F3-Specific

anti- PPIF-Specific antibody

FNab06676 100µg
EUR 505.25
Description: Antibody raised against PPIF-Specific

anti- PPP1CB-Specific antibody

FNab06695 100µg
EUR 505.25
Description: Antibody raised against PPP1CB-Specific

anti- PPP1R11-Specific antibody

FNab06699 100µg
EUR 585
Description: Antibody raised against PPP1R11-Specific

anti- PSEN2-Specific antibody

FNab06853 100µg
EUR 548.75
Description: Antibody raised against PSEN2-Specific

anti- PTH-Specific antibody

FNab06923 100µg
EUR 585
Description: Antibody raised against PTH-Specific

anti- RAB27A-specific antibody

FNab07011 100µg
EUR 505.25
Description: Antibody raised against RAB27A-specific

anti- RAB31-specific antibody

FNab07015 100µg
EUR 505.25
Description: Antibody raised against RAB31-specific

anti- RAB3A-specific antibody

FNab07025 100µg
EUR 505.25
Description: Antibody raised against RAB3A-specific

anti- RAB3C-specific antibody

FNab07028 100µg
EUR 505.25
Description: Antibody raised against RAB3C-specific

anti- REDD1 specific antibody

FNab07228 100µg
EUR 548.75
Description: Antibody raised against REDD1 specific

anti- RIPK1-Specific antibody

FNab07313 100µg
EUR 548.75
Description: Antibody raised against RIPK1-Specific

anti- ROBO4-Specific antibody

FNab07375 100µg
EUR 548.75
Description: Antibody raised against ROBO4-Specific

anti- ROCK1-Specific antibody

FNab07377 100µg
EUR 548.75
Description: Antibody raised against ROCK1-Specific

anti- ROCK2-Specific antibody

FNab07379 100µg
EUR 548.75
Description: Antibody raised against ROCK2-Specific

anti- RRM1-Specific antibody

FNab07495 100µg
EUR 548.75
Description: Antibody raised against RRM1-Specific

anti- RtcB-Specific antibody

FNab07515 100µg
EUR 548.75
Description: Antibody raised against RtcB-Specific

anti- SEC61B-Specific antibody

FNab07691 100µg
EUR 548.75
Description: Antibody raised against SEC61B-Specific

anti- SENP5-Specific antibody

FNab07714 100µg
EUR 548.75
Description: Antibody raised against SENP5-Specific

anti- SERINC2-Specific antibody

FNab07736 100µg
EUR 548.75
Description: Antibody raised against SERINC2-Specific

anti- SIRT2-Specific antibody

FNab07880 100µg
EUR 548.75
Description: Antibody raised against SIRT2-Specific

anti- SLC12A5-Specific antibody

FNab07908 100µg
EUR 548.75
Description: Antibody raised against SLC12A5-Specific

anti- HIP1-Specific antibody

FNab03870 100µg
EUR 548.75
Description: Antibody raised against HIP1-Specific

anti- HMMR-Specific antibody

FNab03936 100µg
EUR 505.25
Description: Antibody raised against HMMR-Specific

anti- HNRNPUL2-Specific antibody

FNab03961 100µg
EUR 585
Description: Antibody raised against HNRNPUL2-Specific

anti- HRAS-Specific antibody

FNab04008 100µg
EUR 585
Description: Antibody raised against HRAS-Specific

anti- HSPG2-Specific antibody

FNab04063 100µg
EUR 548.75
Description: Antibody raised against HSPG2-Specific

anti- IFITM1-Specific antibody

FNab04141 100µg
EUR 585
Description: Antibody raised against IFITM1-Specific

anti- IFITM2-specific antibody

FNab04143 100µg
EUR 585
Description: Antibody raised against IFITM2-specific

anti- IGF1B-Specific antibody

FNab04169 100µg
EUR 548.75
Description: Antibody raised against IGF1B-Specific

anti- IGF2R-Specific antibody

FNab04174 100µg
EUR 585
Description: Antibody raised against IGF2R-Specific

anti- ING1-specific antibody

FNab04309 100µg
EUR 548.75
Description: Antibody raised against ING1-specific

anti- ING3-specific antibody

FNab04312 100µg
EUR 548.75
Description: Antibody raised against ING3-specific

anti- ING4-specific antibody

FNab04314 100µg
EUR 505.25
Description: Antibody raised against ING4-specific

anti- ITPR1-specific antibody

FNab04425 100µg
EUR 505.25
Description: Antibody raised against ITPR1-specific

anti- KCNB1-Specific antibody

FNab04480 100µg
EUR 585
Description: Antibody raised against KCNB1-Specific

anti- KGA-Specific antibody

FNab04520 100µg
EUR 505.25
Description: Antibody raised against KGA-Specific

anti- KISS1R-Specific antibody

FNab04593 100µg
EUR 585
Description: Antibody raised against KISS1R-Specific

anti- KLHL14-Specific antibody

FNab04614 100µg
EUR 548.75
Description: Antibody raised against KLHL14-Specific

anti- KRT10-specific antibody

FNab04649 100µg
EUR 548.75
Description: Antibody raised against KRT10-specific

anti- Kv1.4-Specific antibody

FNab04664 100µg
EUR 505.25
Description: Antibody raised against Kv1.4-Specific

anti- LAMC3-Specific antibody

FNab04680 100µg
EUR 548.75
Description: Antibody raised against LAMC3-Specific

anti- LATS2-Specific antibody

FNab04709 100µg
EUR 548.75
Description: Antibody raised against LATS2-Specific

anti- LC3A-Specific antibody

FNab04719 100µg
EUR 505.25
Description: Antibody raised against LC3A-Specific

anti- LC3B-Specific antibody

FNab04720 100µg
EUR 548.75
Description: Antibody raised against LC3B-Specific

anti- LDHA-Specific antibody

FNab04737 100µg
EUR 548.75
Description: Antibody raised against LDHA-Specific

anti- LDHB-Specific antibody

FNab04739 100µg
EUR 505.25
Description: Antibody raised against LDHB-Specific

anti- LDHC-Specific antibody

FNab04740 100µg
EUR 585
Description: Antibody raised against LDHC-Specific

anti- Lin28A-specific antibody

FNab04784 100µg
EUR 548.75
Description: Antibody raised against Lin28A-specific

anti- Lin28B-specific antibody

FNab04786 100µg
EUR 585
Description: Antibody raised against Lin28B-specific

anti- LRP2-Specific antibody

FNab04847 100µg
EUR 585
Description: Antibody raised against LRP2-Specific

anti- MAS1L-Specific antibody

FNab05020 100µg
EUR 585
Description: Antibody raised against MAS1L-Specific

anti- MCL1L-specific antibody

FNab05054 100µg
EUR 505.25
Description: Antibody raised against MCL1L-specific

anti- MDM1-Specific antibody

FNab05076 100µg
EUR 548.75
Description: Antibody raised against MDM1-Specific

anti- MEF2C-Specific antibody

FNab05107 100µg
EUR 505.25
Description: Antibody raised against MEF2C-Specific

anti- MYH10-Specific antibody

FNab05472 100µg
EUR 505.25
Description: Antibody raised against MYH10-Specific

anti- MYH4-Specific antibody

FNab05476 100µg
EUR 548.75
Description: Antibody raised against MYH4-Specific

anti- MYH7-specific antibody

FNab05478 100µg
EUR 548.75
Description: Antibody raised against MYH7-specific

anti- MYOM1-Specific antibody

FNab05516 100µg
EUR 505.25
Description: Antibody raised against MYOM1-Specific

Induction of protecting immune responses in opposition to a deadly Zika virus problem post-vaccination with a twin serotype of recombinant vesicular stomatitis virus carrying the genetically modified Zika virus E protein gene

The event of a vaccine to forestall Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine in opposition to ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. We’ve employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a kind 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.

Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced robust protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.

Chilly-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β manufacturing 

Background: Gout is an autoinflammatory illness pushed by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β manufacturing relies on inflammasome activation, which requires a priming sign, adopted by an activating sign. The cold-inducible RNA-binding protein (CIRP) has been not too long ago recognized as a damage-associated molecular sample (DAMP). On this research, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1β secretion utilizing human neutrophils. 

Strategies: Human neutrophils had been stimulated by MSU within the presence or absence of CIRP priming to find out NLRP3 inflammasome activation and subsequent caspase-1 activation and IL-1β manufacturing. Mobile supernatants had been analyzed by enzyme-linked immunosorbent assay (ELISA) to find out the presence of IL-1β or caspase-1 (p20). The mobile supernatants and lysates had been additionally analyzed by immunoblotting utilizing anti-cleaved IL-1β or anti-cleaved caspase-1 antibodies.

Outcomes: Neither CIRP nor MSU stimulation alone induced ample IL-1β secretion from neutrophils. Nevertheless, MSU stimulation induced IL-1β secretion from CIRP-primed neutrophils in a dose-dependent method. This MSU-induced IL-1β secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1β (p17), which was inhibited by the pretreatment of MCC950, a selected inhibitor for NLRP3. Moreover, cleaved caspase-1 was induced within the mobile lysates of CIRP/MSU-treated neutrophils. Moreover, CIRP stimulation induced the protein expression of pro-IL-1β in neutrophils. 

Conclusions: Our knowledge point out that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1β induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. We suggest that CIRP acts as an necessary proinflammatory stimulant that primes and prompts inflammasome and pro-IL-1β processing in response to uric acid in innate immune cells.

HDAC-8, human recombinant

7618-100
EUR 588

HDAC-8, human recombinant

7618-1000
EUR 4345

HDAC-8, human recombinant

7618-20
EUR 262

HDAC-IN-3

HY-19772 50mg
EUR 2116

HDAC 3 antibody

20R-1663 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 3 antibody

NCOR2/ Rat NCOR2 ELISA Kit

ELA-E11288r 96 Tests
EUR 886

HDAC 3 Blocking Peptide

33R-10518 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 3 antibody, catalog no. 20R-1663

HDAC-3 Blocking Peptide

3603BP-50
EUR 153

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

NCOR2 Antibody

1-CSB-PA080039
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

NCOR2 Antibody

1-CSB-PA015548GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NCOR2 siRNA

20-abx925532
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

NCOR2 siRNA

20-abx925533
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol

NCOR2 Antibody

43109-100ul 100ul
EUR 252

NCOR2 Antibody

ABD8896 100 ug
EUR 438

NCOR2 Antibody

DF8896 200ul
EUR 304
Description: NCOR2 Antibody detects endogenous levels of total NCOR2.

NCOR2 antibody

70R-18789 50 ul
EUR 435
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 antibody

70R-32241 100 ug
EUR 327
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 antibody

PAab10069 100 ug
EUR 386

anti-NCOR2

YF-PA25381 50 ul
EUR 334
Description: Mouse polyclonal to NCOR2

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Human NCOR2 shRNA Plasmid

20-abx956396
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Human NCOR2 ELISA Kit

ELA-E0334h 96 Tests
EUR 824

NCOR2 ELISA KIT|Human

EF000574 96 Tests
EUR 689

HDAC ELISA KIT|Human

EF010966 96 Tests
EUR 689

GAPDH, Active, human recombinant

P1100-10
EUR 142

GAPDH, Active, human recombinant

P1100-50
EUR 392

PRMT1, human recombinant (Active)

4865-10
EUR 153

PRMT1, human recombinant (Active)

4865-1000
EUR 3834

PRMT1, human recombinant (Active)

4865-50
EUR 392

Active AHCY, human recombinant

7527-10
EUR 262

Active AHCY, human recombinant

7527-1000
EUR 5482

Active AHCY, human recombinant

7527-50
EUR 479

Active Recombinant Human CETP

7606-100
EUR 805

Active Recombinant Human CETP

7606-1000
EUR 4345

Active Recombinant Human CETP

7606-20
EUR 262

Active SIRT2, human recombinant

7698-10
EUR 262

Active SIRT2, human recombinant

7698-1000
EUR 4394

Active SIRT2, human recombinant

7698-50
EUR 457

Active SIRT7, human recombinant

7846-10
EUR 218

Active SIRT7, human recombinant

7846-50
EUR 588

Irisin, Active, human recombinant

7852-10
EUR 370

Irisin, Active, human recombinant

7852-50
EUR 1077

HER2, Active, Human Recombinant

8011-5
EUR 240

HER2, Active, Human Recombinant

8011-50
EUR 1132

NCOR2 sgRNA CRISPR Lentivector (Human) (Target 3)

K1400604 1.0 ug DNA
EUR 154

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

Anti-NCOR2 antibody

STJ110686 100 µl
EUR 277
Description: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

NCOR2 Rabbit pAb

A8388-100ul 100 ul
EUR 308

NCOR2 Rabbit pAb

A8388-200ul 200 ul
EUR 459

NCOR2 Rabbit pAb

A8388-20ul 20 ul
EUR 183

NCOR2 Rabbit pAb

A8388-50ul 50 ul
EUR 223

NCOR2 Conjugated Antibody

C43109 100ul
EUR 397

anti- NCOR2 antibody

FNab05594 100µg
EUR 505.25
Description: Antibody raised against NCOR2

anti- NCOR2 antibody

FNab10069 100µg
EUR 548.75
Description: Antibody raised against NCOR2

NCOR2 Blocking Peptide

DF8896-BP 1mg
EUR 195

Anti-NCOR2 antibody

PAab05594 100 ug
EUR 355

Apicidin (HDAC inhibitor)

SIH-346-1MG 1 mg
EUR 136
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

Apicidin (HDAC inhibitor)

SIH-346-5MG 5 mg
EUR 340
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

HPA (HDAC inhibitor)

SIH-356-10MG 10 mg
EUR 128
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HPA (HDAC inhibitor)

SIH-356-50MG 50 mg
EUR 226
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HDAC-IN-7

HY-13592 10mM/1mL
EUR 215

HDAC Set I

A9906-1 1 Set
EUR 154

HDAC Assay Kit

55R-1371 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit

55R-1372 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC 6 antibody

20R-1667 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 6 antibody

HDAC 7 antibody

20R-1668 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 7 antibody

HDAC 8 antibody

20R-1669 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 8 antibody

HDAC 9 antibody

20R-1670 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 9 antibody

HDAC 10 antibody

20R-1671 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 10 antibody

HDAC 11 antibody

20R-1672 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 11 antibody

HDAC 1 antibody

20R-1661 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 1 antibody

HDAC 2 antibody

20R-1662 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 2 antibody

HDAC 4 antibody

20R-1664 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 4 antibody

20R-1665 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 5 antibody

20R-1666 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 5 antibody

HDAC Substrate, Colorimetric

2207-100
EUR 300

HDAC Substrate, Colorimetric

2207-25
EUR 126

HDAC Substrate, Fluorogenic

2396-25
EUR 512

HDAC Substrate, Fluorogenic

2396-5
EUR 175

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

NCOR2 ELISA Kit (Human) (OKEH04298)

OKEH04298 96 Wells
EUR 662
Description: Description of target: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 100 pg/mL

NCOR2 ORF Vector (Human) (pORF)

ORF025977 1.0 ug DNA
EUR 2730

Caspase-3, active

RA15046 50 ug
EUR 383

Active Blocker 3

abx090803-01g 0.1 g
EUR 411

Recombinant Human Activin-A Active

7-00004 1ug Ask for price

Recombinant Human Activin-A Active

7-00005 5ug Ask for price

Recombinant Human Activin-A Active

7-00006 100µg Ask for price

Recombinant Human Activin-B Active

7-00010 1ug Ask for price

Recombinant Human Activin-B Active

7-00011 5ug Ask for price

Recombinant Human Activin-B Active

7-00012 100µg Ask for price

Active Cathepsin S, human recombinant

7526-10
EUR 338

Active Cathepsin S, human recombinant

7526-50
EUR 1126

Active Cathepsin S, human recombinant

7526-500
EUR 9130

Active Cathepsin B, human recombinant

7580-1000
EUR 9783

Active Cathepsin B, human recombinant

7580-5
EUR 294

Active Cathepsin B, human recombinant

7580-50
EUR 1132

Cathepsin K, Active, human recombinant

7600-5
EUR 392

Cathepsin K, Active, human recombinant

7600-50
EUR 2279

MMP-9, Active, human recombinant

7867-1000
EUR 501

MMP-9, Active, human recombinant

7867-500
EUR 332

Active BCL2L1 Protein, human recombinant

7885-10
EUR 256

Active BCL2L1 Protein, human recombinant

7885-50
EUR 691

MMP-14, Active, Human Recombinant

8009-10
EUR 316

MMP-14, Active, Human Recombinant

8009-50
EUR 805

Active Cathepsin D, Human Recombinant

9229-10
EUR 245

Active Cathepsin D, Human Recombinant

9229-100
EUR 1132

Active Cathepsin D, Human Recombinant

9229-50
EUR 735

5-Lipoxygenase, Active, Human Recombinant

P1373-200
EUR 316

MMP-9, Active, Human Recombinant

P1567-10 10 µg
EUR 348

MMP-9, Active, Human Recombinant

P1567-50 50 µg
EUR 510

Human recombinant UBE2D3

6430-3
EUR 365

Human recombinant UBE2L3

6431-3
EUR 365

LIGHT, Human Recombinant

P1291-3
EUR 175

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03937 3µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03938 10µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03939 20µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04360 2µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04361 10µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04362 1mg Ask for price

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-3 Regular: 10ug
EUR 317
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

Human CellExp? HDAC6, Human Recombinant, Active

P1265-50
EUR 446

Human CellExp? HDAC8, Human Recombinant, Active

P1266-50
EUR 446

Human CellExp? HDAC11, Human Recombinant, Active

P1267-50
EUR 446

Recombinant Human TPO Protein

PROTP40225-3 10ug
EUR 317
Description: TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant human TPO is a fully biologically active 174 amino acid polypeptide (18.6 kDa), which contains the erythropoietin-like domain of the full length TPO protein.

Recombinant Human Leptin Protein

PROTP41159-3 1mg
EUR 317
Description: Encoded by the ob (obese) gene, Leptin is an adipose-derived cytokine that suppresses appetite and increases thermogenesis. Leptin exerts its anorectic effect via signaling through a hypothalamic receptor termed OB-R. Leptin has been shown to reduce body weight, food consumption, and plasma glucose levels in various in vivo models. Recombinant human Leptin is a 16.0 kDa protein containing 147 amino acid residues.

Recombinant Human Sox2 Protein

PROTP48431-3 25ug
EUR 317
Description: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Recombinant human Sox2 is a 34.3 kDa protein containing 317 amino-acid residues.

Recombinant Human NOGGIN Protein

PROTQ13253-3 20ug
EUR 317
Description: Noggin belongs to a group of diffusible proteins which bind to ligands of the TGF-β family and regulate their activity by inhibiting their access to signaling receptors. The interplay between TGF-β ligands and their natural antagonists has major biological significance during development processes, in which cellular response can vary considerably depending upon the local concentration of the signaling molecule. Noggin was originally identified as a BMP-4 antagonist whose action is critical for proper formation of the head and other dorsal structures. Consequently, Noggin has been shown to modulate the activities of other BMPs including BMP-2,-7,-13, and -14. Targeted deletion of Noggin in mice results in prenatal death and recessive phenotype displaying a severely malformed skeletal system. Conversely, transgenic mice over-expressing Noggin in mature osteoblasts display impaired osteoblastic differentiation, reduced bone formation, and severe osteoporosis. Recombinant human Noggin is a 46 kDa disulfide-linked homodimer (120-10C) consisting of two 206 amino acid polypeptide chains. Monomeric glycosylated Noggin migrates at an apparent molecular weight of approximately 28.0-33.0 kDa by SDS PAGE analysis under reducing conditions.

Recombinant Human Epigen Protein

PROTQ6UW88-3 25ug
EUR 317
Description: Epigen is an EGF-related polypeptide growth factor that signals through the ErbB receptor-1. It is produced in several tissues, including the testis, liver, heart and in certain tumor cells. Epigen is mitogenic for fibroblasts and epithelial cells. Human Epigen is initially synthesized as a glycosylated 14.7 kDa transmembrane precursor protein, which is processed by proteolytic cleavage to produce a mature soluble sequence. Recombinant human Epigen is a 7.9kDa monomeric protein, containing 72 amino acid residues, which comprises the EGF homologous portion of the Epigen precursor.

Recombinant Human Chemerin Protein

PROTQ99969-3 25ug
EUR 317
Description: Chemerin is a secreted chemoattractant protein that can signal through the chemokine like receptor-1 (CMKLR1). It is expressed in various tissues, including white adipose tissue, and circulates in blood as an inactive 143 amino acid precursor protein. Biologically active Chemerin is generated by proteolytic removal of C-terminal residues by several circulating proteases. Chemerin acts as a chemoattractant for cells expressing the CMKLR1 receptor, which includes certain dendritic cells, macrophages, and adipocytes. Recombinant human Chemerin is a 15.6 kDa protein consisting of 135 amino acid residues.

Recombinant Human Nanog Protein

PROTQ9H9S0-3 20ug
EUR 317
Description: Nanog is a regulatory protein that is associated with undifferentiated pluripotent cells. The expression of Nanog, which is suppressed in all adult tissues, is restricted to embryonic stem cells and to certain pluripotent cancer cells. Decreased expression of Nanog is strongly correlated with cell differentiation. Nanog, most likely, acts as an intracellular regulator, which maintains pluripotency and self renewal via a STAT3 independent pathway. Recombinant human Nanog is a 34.5 kDa protein, which is synthesized as a 304 amino acid polypeptide lacking a signal sequence for secretion.

Recombinant Human Tigar Protein

PROTQ9NQ88-3 25ug
EUR 317
Description: TIGAR is a p53-inducible enzyme that catalyzes the hydrolysis of fructose-2-6 bisphosphate (F-2-6-BP) to fructose-6-phosphate and inorganic phosphate. F-2-6-BP is a powerful activator of 6-phosphofructose-1 kinase, the rate limiting enzyme of glycolysis. By lowering the intracellular level of F-2-6-BP, TIGAR expression leads to increased glucose processing via the pentose phosphate pathway, the major cellular source for NADPH. Recombinant human TIGAR expressed in E. coli is a 29.9 kDa protein containing 269 amino-acid residues.

Recombinant Human AITRL Protein

PROTQ9UNG2-3 20ug
EUR 317
Description: AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177 amino acids, including a 28 amino acid cytoplasmic region, a 21 amino acid transmembrane domain and a 128 amino acid extracellular domain. Recombinant human soluble AITRL is a 14.4 kDa protein, containing 127 amino acid residues corresponding to the extracellular domain of AITRL.

Recombinant Human BAFF Protein

PROTQ9Y275-3 20ug
EUR 317
Description: BAFF, a member of the TNF family of ligands, is expressed in T cells, macrophages, monocytes and dendritic cells. BAFF is involved in stimulation of B and T cell function, and is an important survival and maturation factor for peripheral B cells. BAFF signals through three different TNF receptors TACI, BCMA and BAFF-R. The human BAFF gene codes for a 285 amino acid type II transmembrane protein containing a 46 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain, and a 218 amino acid extracellular domain. Recombinant human soluble BAFF is a 152 amino acid polypeptide (17.0 kDa), which contains the TNF-like portion of the extracellular domain of BAFF.

Recombinant Human ApoE3 Protein

PROTP02649-3 500ug
EUR 317
Description: ApoE3 belongs to a group of proteins that bind reversibly with lipoprotein and play an important role in lipid metabolism. In addition to facilitating solublization of lipids, these proteins help to maintain the structural integrity of lipoproteins, serve as ligands for lipoprotein receptors, and regulate the activity of enzymes involved in lipid metabolism. Significant quantities of ApoE are produced in liver and brain and to some extent in almost every organ. ApoE exists in three major isoforms; E2, E3, and E4, which differ from one another by a single amino-acid substitution. E3 is the most common isoform and is present in 40-90% of the population. Recombinant human ApoE3 is a 34.0 kDa protein containing 299 amino acid residues.

Recombinant Human sCD14 Protein

PROTP08571-3 50ug
EUR 317
Description: CD14 is a cell surface anchored glycoprotein that is expressed predominantly by monocytes and tissue macrophages. CD14 associates with MD-2 (LY-96) and TLR4 to form a receptor complex, which signals specifically in response to bacterial lipopolysaccharide (LPS) binding. The CD14/MD-2/TLR4 receptor complex signals via MyD88, TIRAP, and TRAF6, and ultimately activates NF-kappaB. CD14 also exists in a soluble form, designated as sCD14, which is capable of specifically binding LPS in the extracellular space. Recombinant sCD14 is a 331 amino acid glycoprotein comprising the extracellular portion of the CD14 receptor.

Recombinant Human Follistatin Protein

PROTP19883-3 20ug
EUR 317
Description: Follistatin is a secreted protein that binds to ligands of the TGF-β family and regulates their activity by inhibiting their access to signaling receptors. It was originally discovered as activin antagonists whose activity suppresses expression and secretion of the pituitary hormone FSH (follicle stimulating hormone). In addition to being a natural antagonist, follistatin can inhibit the activity of other TGF-β ligands including BMP-2,-4,-6,-7, Myostatin, GDF-11, and TGF-β1. Follistatin is expressed in the pituitary, ovaries, decidual cells of the endometrium, and in some other tissues. Recombinant human Follistatin is a 31.5 kDa protein containing 288 amino acids. Its primary structure contains three cysteine-rich domains (called FS domains), each followed by a protease-inhibitory kazal domain.

Recombinant Human SCF Protein

PROTP21583-3 10ug
EUR 317
Description: Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity by signaling through the c-Kit receptor. SCF and c-Kit are essential for the survival, proliferation and differentiation of hematopoietic cells committed to the melanocyte and germ cell lineages. Human SCF manifests low activity on murine cells, while murine and rat SCF are fully active on human cells. Recombinant human SCF is an 18.4 kDa polypeptide containing 165 amino acid residues, which corresponds to the sequence of the secreted soluble form of SCF.

Recombinant Human BDNF Protein

PROTP23560-3 10ug
EUR 317
Description: BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical.

Recombinant Human CNTF Protein

PROTP26441-3 20ug
EUR 317
Description: CNTF is a potent neural factor that was originally characterized as a vital factor for the survival of chick ciliary neurons in vitro. CNTF is also important for the survival of other neural cell types including primary sensory neurons, motor neurons, basal forebrain neurons and type 2 astrocytes. CNTF is highly conserved across species and exhibits cross-species bioactivity. Recombinant human CNTF is synthesized as a 199 amino acid polypeptide (22.8 kDa) lacking a hydrophobic N-terminal signal for secretion.

Recombinant Human sCD34 Protein

PROTP28906-3 20ug
EUR 317
Description: CD34 is a highly glycosylated type I membrane protein that is selectively expressed on hematopoietic stem cells and vascular endothelium. It has been widely used as a molecular marker for the identification, isolation, and manipulation of hemopoietic stem cells and progenitors. CD34 can function as a regulator of hemopoietic cell adhesion by mediating the attachment of stem cells to bone marrow stromal cells or other bone marrow components. The full length human CD34 is a 385 amino acid protein, consisting of a 31 amino acid signal sequence, a 74 amino acid cytoplasmic domain, a 21 amino acid transmembrane domain and a 259 amino acid extracellular domain. Recombinant human sCD34 is a 258 amino acid polypeptide containing only the extracellular domain of the full length CD34 protein.

Recombinant Human CTGF Protein

PROTP29279-3 20ug
EUR 317
Description: CTGF is a member of the CCN family of secreted cysteine rich regulatory proteins and is the major mitogenic and chemoattractant protein produced by umbilical vein and vascular endothelial cells. CTGF stimulates the proliferation and differentiation of chondrocytes, induces angiogenesis, promotes cell adhesion of fibroblasts, endothelial, and epithelial cells, and binds to IGF, TGF β1, and BMP-4. Cell migration and adhesion are signaled through binding to specific cell surface integrins and to heparin sulfate proteoglycans CTGF (98 a.a.), a lower molecular weight isoform containing the C-terminal portion of the full length CTGF protein, exerts full heparin binding, cell adhesion, and mitogenic CTGF activity. Recombinant human CTGF is a 11.0 kDa protein of 97 amino acid residues.

Recombinant Human PEDF Protein

PROTP36955-3 20ug
EUR 317
Description: PEDF is a noninhibitory serpin with neurotrophic, anti-angiogenic, and anti-tumorigenic properties. It is a 50 kDa glycoprotein produced and secreted in many tissues throughout the body. A major component of the anti-angiogenic action of PEDF is the induction of apoptosis in proliferating endothelial cells. In addition, PEDF is able to inhibit the activity of angiogenic factors such as VEGF and FGF-2. The neuroprotective effects of PEDF are achieved through suppression of neuronal apoptosis induced by peroxide, glutamate, or other neurotoxins. The recent identification of a lipase-linked cell membrane receptor for PEDF (PEDF-R) that binds to PEDF with high affinity (1) should facilitate further elucidation of the underlying mechanisms of this pluripotent serpin. To date, PEDF-R is the only signaling receptor known to be used by a serpin family member. The unique range of PEDF activities implicate it as a potential therapeutic agent for the treatment of vasculature related neurodegenerative diseases such as age-related macular degeneration (AMD) and proliferative diabetic retinopathy (PDR). PEDF also has the potential to be useful in the treatment of various angiogenesis-related diseases including a number of cancers. Recombinant PEDF is a 44.5 kDa non-glycosylated protein containing 400 amino acid residues. (1) Notari, I. et al. J Biol Chem., Vol. 281, 38022-38037.

Human CCL4 Recombinant Protein

R00703-3 5ug/vial
EUR 259
Description: The small chemotactic cytokine CCL4 (MIP-1 beta) is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells. CCL4 is involved in several inflammatory and autoimmune diseases including viral infection such as HIV-1/AIDS. Human CCL4 Recombinant Protein is purified chemokine ligand 4 (CCL4, MIP-1 beta) produced in yeast.

Human CXCL9 Recombinant Protein

R01397-3 5ug/vial
EUR 259
Description: CXCL9 (MIG) is a T-cell chemoattractant. Induced by IFN-gamma (IFN-γ), the ELR-negative chemokine CXCL9 (MIG) elicits its effects by binding to the cell surface chemokine receptor CXCR3. Human CXCL9 Recombinant Protein is purified CXCL9 (MIG) produced in yeast.

Human recombinant UBE2R1 (CDC34)

6436-3
EUR 365

Human recombinant UBE2R2 (Ubc3B)

6437-3
EUR 392

Human recombinant UBE2E2 (UbcH8)

6438-3
EUR 392

sIL-4R?, Human Recombinant

P1287-3
EUR 175

Ncor2 sgRNA CRISPR Lentivector (Mouse) (Target 3)

K4359604 1.0 ug DNA
EUR 154

Ncor2 sgRNA CRISPR Lentivector (Rat) (Target 3)

K7301604 1.0 ug DNA
EUR 154

NCOR2 3'UTR GFP Stable Cell Line

TU065325 1.0 ml
EUR 1521

Ncor2 3'UTR Luciferase Stable Cell Line

TU213797 1.0 ml Ask for price

Ncor2 3'UTR GFP Stable Cell Line

TU263797 1.0 ml Ask for price

NCOR2 3'UTR Luciferase Stable Cell Line

TU015325 1.0 ml
EUR 1521

Ncor2 3'UTR Luciferase Stable Cell Line

TU113901 1.0 ml Ask for price

Ncor2 3'UTR GFP Stable Cell Line

TU163901 1.0 ml Ask for price

Mouse NCOR2 shRNA Plasmid

20-abx972783
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg

Trichostatin A (HDAC inhibitor)

SIH-254-1MG 1 mg
EUR 206
Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Trichostatin A (HDAC inhibitor)

SIH-254-5MG 5 mg
EUR 613
Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)

SIH-255-100MG 100 mg
EUR 93
Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)

SIH-255-500MG 500 mg
EUR 127
Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Bml-210 (HDAC inhibitor)

SIH-348-25MG 25 mg
EUR 866
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Bml-210 (HDAC inhibitor)

SIH-348-5MG 5 mg
EUR 266
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Sodium Valproate (HDAC inhibitor)

SIH-357-5G 5 g
EUR 95
Description: The substance Sodium Valproate is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml Water.

SAHA (Vorinostat) (HDAC inhibitor)

SIH-359-250MG 250 mg
EUR 329
Description: The substance SAHA (Vorinostat) is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol.

Leave a Reply

Your email address will not be published.