DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

Vincent May 12, 2021 0 Comments
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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown

Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis.

Strategies & outcomes: Myeloid particular PHD knockout (PHDko) mice had been obtained through bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown by means of lysozyme M-driven Cre recombinase (PHD2cko). Mice had been fed excessive ldl cholesterol eating regimen for 6-12 weeks to induce atherosclerosis. Aortic root plaque measurement was considerably augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko in comparison with controls, however was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, through the HIF1α/BNIP3 axis. Bulk and single cell RNA knowledge of PHD2cko bone-marrow-derived macrophages (BMDM) and plaque macrophages, respectively, confirmed enhanced HIF1α/BNIP3 signaling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively related to plaque necrotic core measurement, suggesting comparable pro-apoptotic results in human.

Additional, PHD2cko plaques displayed enhanced fibrosis, whereas macrophage collagen breakdown by matrix metalloproteinases, collagen manufacturing and proliferation had been unaltered. As an alternative, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine method. In silico evaluation of macrophage-fibroblast communication predicted SPP1 (osteopontin) signaling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Elevated SPP1 mRNA expression upon PHD2cko was preferentially noticed in foamy plaque macrophages expressing “triggering receptor expressed on myeloid cells-2” (TREM2hi) evidenced by single-cell RNA, however not in neutrophils. This confirmed enhanced fibrotic signaling by PHD2cko macrophages to fibroblasts, in vitro in addition to in vivo.

Conclusion: Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque progress and macrophage apoptosis, whereas PHD2cko macrophages additional activated collagen secretion by fibroblasts in vitro, possible through paracrine SPP1 signaling by means of TREM2hi macrophages.

Translational outlook: This research exhibits that myeloid PHD isoforms PHD2 and PHD3 worsen plaque traits and phenotype, corresponding to plaque measurement, macrophage accumulation, apoptosis, and collagen accumulation in mice. We present each direct results on macrophages and paracrine results of macrophage PHD2 loss on vessel wall fibroblast populations. Broad spectrum-PHD inhibitors, e.g. Roxadustat, are presently being prescribed to power kidney illness sufferers, who’re already in danger for heart problems. When contemplating this research and the pro-fibrotic and pro-apoptotic results we report, broad PHD inhibition might due to this fact be sub-optimal and extra focused PHD inhibition of PHD1 must be thought of.

The results of various temperatures of post-exercise protein-containing drink on gastric motility and power consumption in wholesome younger males 

The current research examined the consequences of various temperatures of protein-containing drink after train on subsequent gastric motility and power consumption in wholesome younger males. Twelve wholesome younger males accomplished three, one-day trials in a random order. In all trials, the topics ran on a treadmill for 30 min at 80% of most coronary heart fee. In train + chilly drink (2 °C) and train + sizzling drink (60 °C) trials, the topics consumed 300 mL of protein-containing drink (0.34 MJ) at 2 °C or 60 °C over a 5-min interval after train. Within the train (i.e., no preload) trial, the topics sat on a chair for five min after train. Then, the topics sat on a chair for 30 min to measure their gastric motility with an ultrasound imaging system in all trials.

Thereafter, the topics consumed a take a look at meal till they felt comfortably full. Vitality consumption within the train + sizzling drink trial was 14 % and 15 % greater than the train (P=0.046, 95% CI: 4.010-482.538) trial and train + chilly drink (P=0.001, 95% CI: 160.089-517.111) trial, respectively. The frequency of the gastric contractions within the train + sizzling drink trial was greater than the train (P=0.023) trial and train + chilly drink (P=0.007) trial. The overall frequency of gastric contractions was positively associated to power consumption (r=0.386, P=0.022). These findings reveal that consuming protein-containing drink after train at 60 °C will increase power consumption and that this improve could also be associated to the modulation of the gastric motility.

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Description: Mouse polyclonal to Human Milk Fat Globule 1

anti-Human Milk Fat Globule 1
YF-PA13136 100 ul
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Description: Rabbit polyclonal to Human Milk Fat Globule 1

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Description: Rabbit polyclonal to Human Milk Fat Globule 1

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PAab00565 100 ug
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PAab00661 100 ug
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PAab00788 100 ug
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PAab00791 100 ug
EUR 426

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PAab00792 100 ug
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PAab00963 100 ug
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Anti-SLC12A5-Specific antibody
PAab07908 100 ug
EUR 463.2

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PAab07947 100 ug
EUR 463.2

Anti-SLIT2-Specific antibody
PAab07981 100 ug
EUR 463.2

Anti-SMYD1-Specific antibody
PAab08047 100 ug
EUR 463.2

Anti-Somatostatin-Specific antibody
PAab08109 100 ug
EUR 463.2

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PAab08142 100 ug
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Anti-SPIN1-Specific antibody
PAab08178 100 ug
EUR 494.4

Anti-SPTBN1-Specific antibody
PAab08204 100 ug
EUR 463.2

Anti-SRGAP3-Specific antibody
PAab08227 100 ug
EUR 463.2

Anti-ST8SIA2-Specific antibody
PAab08276 100 ug
EUR 463.2

Anti-STEAP2-Specific antibody
PAab08317 100 ug
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Anti-SURVIVIN-Specific antibody
PAab08403 100 ug
EUR 426

Anti-SYN1-Specific antibody
PAab08416 100 ug
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PAab08484 100 ug
EUR 494.4

Anti-TDRKH specific antibody
PAab08580 100 ug
EUR 463.2

Anti-TGFBR3-Specific antibody
PAab08645 100 ug
EUR 494.4

Anti-TINAG-Specific antibody
PAab08712 100 ug
EUR 494.4

Anti-TMF1-Specific antibody
PAab08796 100 ug
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Anti-TOP2A-Specific antibody
PAab08868 100 ug
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Anti-Tuberin-Specific antibody
PAab09101 100 ug
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Anti-TWIST1-specific antibody
PAab09118 100 ug
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Anti-UBASH3A-Specific antibody
PAab09150 100 ug
EUR 463.2

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PAab09159 100 ug
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PAab09167 100 ug
EUR 463.2

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PAab09202 100 ug
EUR 463.2

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PAab09286 100 ug
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PAab09469 100 ug
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PAab09563 100 ug
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PAab09637 100 ug
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Anti-ZNF600-Specific antibody
PAab09718 100 ug
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Anti-ZNRF2-Specific antibody
PAab09746 100 ug
EUR 463.2

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PAab01249 100 ug
EUR 426

Anti-Catalase-Specific antibody
PAab01302 100 ug
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PAab01377 100 ug
EUR 426

Anti-CCKBR-specific antibody
PAab01378 100 ug
EUR 426

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PAab01390 100 ug
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PAab01401 100 ug
EUR 426

Anti-CD68-Specific antibody
PAab01493 100 ug
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PAab01546 100 ug
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PAab01552 100 ug
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PAab01578 100 ug
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Anti-CEP350-Specific antibody
PAab01603 100 ug
EUR 426

Anti-CES7-Specific antibody
PAab01618 100 ug
EUR 426

Anti-CHST13-Specific antibody
PAab01693 100 ug
EUR 463.2

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PAab01932 100 ug
EUR 426

Anti-CPT1B-specific antibody
PAab01944 100 ug
EUR 463.2

Anti-CPT1C-specific antibody
PAab01946 100 ug
EUR 426

Anti-CRLS1-Specific antibody
PAab01983 100 ug
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PAab02033 100 ug
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PAab02041 100 ug
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PAab02078 100 ug
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Anti-CXCR7-Specific antibody
PAab02107 100 ug
EUR 463.2

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PAab02148 100 ug
EUR 426

Anti-CYP2E1-Specific antibody
PAab02159 100 ug
EUR 426

Anti-CYP4F11-Specific antibody
PAab02171 100 ug
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Anti-CYP4Z1-Specific antibody
PAab02175 100 ug
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Anti-DAPK2-Specific antibody
PAab02241 100 ug
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Anti-DCC-Specific antibody
PAab02262 100 ug
EUR 426

Anti-DGKK-Specific antibody
PAab02360 100 ug
EUR 494.4

Anti-DLL1-Specific antibody
PAab02415 100 ug
EUR 494.4

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PAab02493 100 ug
EUR 426

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PAab02530 100 ug
EUR 494.4

Anti-EDG7-Specific antibody
PAab02635 100 ug
EUR 426

Anti-EGFR-Specific antibody
PAab02669 100 ug
EUR 426

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PAab02697 100 ug
EUR 426

Anti-EIF2C3-Specific antibody
PAab02698 100 ug
EUR 426

Anti-EPHA1-specific antibody
PAab02801 100 ug
EUR 463.2

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PAab02804 100 ug
EUR 426

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PAab02937 100 ug
EUR 494.4

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PAab03004 100 ug
EUR 494.4

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PAab03063 100 ug
EUR 494.4

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PAab03091 100 ug
EUR 426

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PAab03169 100 ug
EUR 463.2

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PAab03171 100 ug
EUR 463.2

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PAab03196 100 ug
EUR 463.2

Anti-FOXL2-Specific antibody
PAab03199 100 ug
EUR 426

Anti-GAB3-Specific antibody
PAab03273 100 ug
EUR 426

Anti-GABARAPL1-Specific antibody
PAab03276 100 ug
EUR 426

Anti-GABARAPL2-Specific antibody
PAab03278 100 ug
EUR 426

Anti-GAC-specific antibody
PAab03290 100 ug
EUR 426

Anti-GATA4-Specific antibody
PAab03363 100 ug
EUR 426

Anti-GEFT-Specific antibody
PAab03416 100 ug
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PAab03477 100 ug
EUR 426

Anti-GLI3-Specific antibody
PAab03478 100 ug
EUR 426

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PAab03587 100 ug
EUR 494.4

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PAab03592 100 ug
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PAab03596 100 ug
EUR 426

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PAab03612 100 ug
EUR 494.4

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PAab03616 100 ug
EUR 463.2

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PAab03767 100 ug
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PAab03771 100 ug
EUR 494.4

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PAab03773 100 ug
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PAab03776 100 ug
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PAab03780 100 ug
EUR 494.4

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PAab03795 100 ug
EUR 426

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PAab03797 100 ug
EUR 426

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PAab03799 100 ug
EUR 463.2

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PAab03801 100 ug
EUR 426

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PAab03802 100 ug
EUR 494.4

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PAab03804 100 ug
EUR 426

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PAab03870 100 ug
EUR 463.2

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PAab03936 100 ug
EUR 426

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PAab03961 100 ug
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PAab04063 100 ug
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PAab04314 100 ug
EUR 426

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EUR 426

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PAab04480 100 ug
EUR 494.4

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PAab04520 100 ug
EUR 426

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EUR 494.4

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PAab04614 100 ug
EUR 463.2

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EUR 426

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PAab04680 100 ug
EUR 463.2

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EUR 463.2

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EUR 426

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EUR 426

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EUR 463.2

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EUR 463.2

Anti-PLOD2-Specific antibody
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EUR 426

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Induction of protecting immune responses in opposition to a deadly Zika virus problem post-vaccination with a twin serotype of recombinant vesicular stomatitis virus carrying the genetically modified Zika virus E protein gene

The event of a vaccine to forestall Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine in opposition to ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. We’ve employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a kind 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.

Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced robust protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.

Chilly-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β manufacturing 

Background: Gout is an autoinflammatory illness pushed by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β manufacturing relies on inflammasome activation, which requires a priming sign, adopted by an activating sign. The cold-inducible RNA-binding protein (CIRP) has been not too long ago recognized as a damage-associated molecular sample (DAMP). On this research, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1β secretion utilizing human neutrophils. 

Strategies: Human neutrophils had been stimulated by MSU within the presence or absence of CIRP priming to find out NLRP3 inflammasome activation and subsequent caspase-1 activation and IL-1β manufacturing. Mobile supernatants had been analyzed by enzyme-linked immunosorbent assay (ELISA) to find out the presence of IL-1β or caspase-1 (p20). The mobile supernatants and lysates had been additionally analyzed by immunoblotting utilizing anti-cleaved IL-1β or anti-cleaved caspase-1 antibodies.

Outcomes: Neither CIRP nor MSU stimulation alone induced ample IL-1β secretion from neutrophils. Nevertheless, MSU stimulation induced IL-1β secretion from CIRP-primed neutrophils in a dose-dependent method. This MSU-induced IL-1β secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1β (p17), which was inhibited by the pretreatment of MCC950, a selected inhibitor for NLRP3. Moreover, cleaved caspase-1 was induced within the mobile lysates of CIRP/MSU-treated neutrophils. Moreover, CIRP stimulation induced the protein expression of pro-IL-1β in neutrophils. 

Conclusions: Our knowledge point out that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1β induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. We suggest that CIRP acts as an necessary proinflammatory stimulant that primes and prompts inflammasome and pro-IL-1β processing in response to uric acid in innate immune cells.

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7618-100
EUR 705.6

HDAC-8, human recombinant
7618-1000
EUR 5214

HDAC-8, human recombinant
7618-20
EUR 314.4

HDAC 3 antibody
20R-1663 100 ug
EUR 807.6
Description: Rabbit polyclonal HDAC 3 antibody

HDAC-IN-3
HY-19772 50mg
EUR 2539.2

NCOR2/ Rat NCOR2 ELISA Kit
ELA-E11288r 96 Tests
EUR 1063.2

HDAC-3 Blocking Peptide
3603BP-50
EUR 183.6

HDAC 3 Blocking Peptide
33R-10518 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 3 antibody, catalog no. 20R-1663

NCOR2 Antibody
43109-100ul 100ul
EUR 302.4

NCOR2 antibody
70R-18789 50 ul
EUR 522
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 antibody
70R-32241 100 ug
EUR 392.4
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 Antibody
ABD8896 100 ug
EUR 525.6

NCOR2 Antibody
1-CSB-PA080039
  • EUR 266.40
  • EUR 234.00
  • 100ug
  • 50ug
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

NCOR2 siRNA
20-abx925532
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

NCOR2 siRNA
20-abx925533
  • EUR 661.20
  • EUR 878.40
  • 15 nmol
  • 30 nmol

NCOR2 Antibody
1-CSB-PA015548GA01HU
  • EUR 716.40
  • EUR 399.60
  • 150ul
  • 50ul
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NCOR2 Antibody
DF8896 200ul
EUR 420

NCOR2 antibody
PAab10069 100 ug
EUR 463.2

anti-NCOR2
YF-PA25381 50 ul
EUR 400.8
Description: Mouse polyclonal to NCOR2

Recombinant TMPRSS2 Protein, Partial
E80017
  • EUR 423.50
  • EUR 660.00
  • EUR 2321.00
  • 20 ul
  • 100 ul
  • 1 ml

Human NCOR2 shRNA Plasmid
20-abx956396
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

NCOR2 ELISA KIT|Human
EF000574 96 Tests
EUR 826.8

Human NCOR2 ELISA Kit
ELA-E0334h 96 Tests
EUR 988.8

Recombinant Transmembrane Protease Serine 2 Protein, Partial
E80016
  • EUR 470.80
  • EUR 753.50
  • EUR 1824.90
  • 20 ul
  • 100 ul
  • 500 ul

Recombinant Novel Coronavirus Spike Glycoprotein(S), Partial
E80018
  • EUR 388.30
  • EUR 860.20
  • EUR 4888.40
  • 20 ul
  • 100 ul
  • 1 ml

Recombinant Human MMP-3 Protein
PROTP08254-3 10ug
EUR 380.4
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

HDAC ELISA KIT|Human
EF010966 96 Tests
EUR 826.8

NCOR2 sgRNA CRISPR Lentivector (Human) (Target 3)
K1400604 1.0 ug DNA
EUR 184.8

IL-3 Interleukin-3 Human Recombinant Protein, His Tag
PROTP08700-3 Regular: 50ug
EUR 380.4
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

NCOR2 Rabbit pAb
A8388-100ul 100 ul
EUR 369.6

NCOR2 Rabbit pAb
A8388-200ul 200 ul
EUR 550.8

NCOR2 Rabbit pAb
A8388-20ul 20 ul
EUR 219.6

NCOR2 Rabbit pAb
A8388-50ul 50 ul
EUR 267.6

NCOR2 Conjugated Antibody
C43109 100ul
EUR 476.4

NCOR2 Blocking Peptide
DF8896-BP 1mg
EUR 234

Anti-NCOR2 antibody
PAab05594 100 ug
EUR 426

anti- NCOR2 antibody
FNab05594 100µg
EUR 606.3
Description: Antibody raised against NCOR2

anti- NCOR2 antibody
FNab10069 100µg
EUR 658.5
Description: Antibody raised against NCOR2

Anti-NCOR2 antibody
STJ110686 100 µl
EUR 332.4
Description: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

PRMT1, human recombinant (Active)
4865-10
EUR 183.6

PRMT1, human recombinant (Active)
4865-1000
EUR 4600.8

PRMT1, human recombinant (Active)
4865-50
EUR 470.4

HER2, Active, Human Recombinant
8011-5
EUR 288

HER2, Active, Human Recombinant
8011-50
EUR 1358.4

Active AHCY, human recombinant
7527-10
EUR 314.4

Active AHCY, human recombinant
7527-1000
EUR 6578.4

Active AHCY, human recombinant
7527-50
EUR 574.8

Active Recombinant Human CETP
7606-100
EUR 966

Active Recombinant Human CETP
7606-1000
EUR 5214

Active Recombinant Human CETP
7606-20
EUR 314.4

Active SIRT2, human recombinant
7698-10
EUR 314.4

Active SIRT2, human recombinant
7698-1000
EUR 5272.8

Active SIRT2, human recombinant
7698-50
EUR 548.4

Active SIRT7, human recombinant
7846-10
EUR 261.6

Active SIRT7, human recombinant
7846-50
EUR 705.6

Irisin, Active, human recombinant
7852-10
EUR 444

Irisin, Active, human recombinant
7852-50
EUR 1292.4

GAPDH, Active, human recombinant
P1100-10
EUR 170.4

GAPDH, Active, human recombinant
P1100-50
EUR 470.4

HDAC Assay Kit
55R-1371 100 assays
EUR 807.6
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit
55R-1372 100 assays
EUR 807.6
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC 1 antibody
20R-1661 100 ug
EUR 807.6
Description: Rabbit polyclonal HDAC 1 antibody

HDAC 2 antibody
20R-1662 100 ug
EUR 807.6
Description: Rabbit polyclonal HDAC 2 antibody

HDAC 4 antibody
20R-1664 100 ug
EUR 794.4
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 4 antibody
20R-1665 100 ug
EUR 807.6
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 5 antibody
20R-1666 100 ug
EUR 794.4
Description: Rabbit polyclonal HDAC 5 antibody

HDAC 6 antibody
20R-1667 100 ug
EUR 754.8
Description: Rabbit polyclonal HDAC 6 antibody

HDAC 7 antibody
20R-1668 100 ug
EUR 754.8
Description: Rabbit polyclonal HDAC 7 antibody

HDAC 8 antibody
20R-1669 100 ug
EUR 754.8
Description: Rabbit polyclonal HDAC 8 antibody

HDAC 9 antibody
20R-1670 100 ug
EUR 781.2
Description: Rabbit polyclonal HDAC 9 antibody

HDAC 10 antibody
20R-1671 100 ug
EUR 754.8
Description: Rabbit polyclonal HDAC 10 antibody

HDAC 11 antibody
20R-1672 100 ug
EUR 781.2
Description: Rabbit polyclonal HDAC 11 antibody

HDAC Substrate, Colorimetric
2207-100
EUR 360

HDAC Substrate, Colorimetric
2207-25
EUR 151.2

HDAC Substrate, Fluorogenic
2396-25
EUR 614.4

HDAC Substrate, Fluorogenic
2396-5
EUR 210

HDAC Set I
A9906-1 1 Set
EUR 184.8

HDAC-IN-7
HY-13592 10mM/1mL
EUR 258

Apicidin (HDAC inhibitor)
SIH-346-1MG 1 mg
EUR 163.2
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

Apicidin (HDAC inhibitor)
SIH-346-5MG 5 mg
EUR 408
Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

HPA (HDAC inhibitor)
SIH-356-10MG 10 mg
EUR 153.6
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HPA (HDAC inhibitor)
SIH-356-50MG 50 mg
EUR 271.2
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

NCOR2 ELISA Kit (Human) (OKEH04298)
OKEH04298 96 Wells
EUR 794.4
Description: Description of target: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 100 pg/mL

NCOR2 ORF Vector (Human) (pORF)
ORF025977 1.0 ug DNA
EUR 3276

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9
PROTP49763-3 Regular: 25ug
EUR 380.4
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant
PROTP10600-3 Regular: 5ug
EUR 380.4
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

Active Blocker 3
abx090803-01g 0.1 g
EUR 493.2

Caspase-3, active
RA15046 50 ug
EUR 459.6

Recombinant Human Activin-A Active
7-00004 1ug Ask for price

Recombinant Human Activin-A Active
7-00005 5ug Ask for price

Recombinant Human Activin-A Active
7-00006 100µg Ask for price

Recombinant Human Activin-B Active
7-00010 1ug Ask for price

Recombinant Human Activin-B Active
7-00011 5ug Ask for price

Recombinant Human Activin-B Active
7-00012 100µg Ask for price

MMP-14, Active, Human Recombinant
8009-10
EUR 379.2

MMP-14, Active, Human Recombinant
8009-50
EUR 966

Active Cathepsin D, Human Recombinant
9229-10
EUR 294

Active Cathepsin D, Human Recombinant
9229-100
EUR 1358.4

Active Cathepsin D, Human Recombinant
9229-50
EUR 882

Active Cathepsin S, human recombinant
7526-10
EUR 405.6

Active Cathepsin S, human recombinant
7526-50
EUR 1351.2

Active Cathepsin S, human recombinant
7526-500
EUR 10956

Active Cathepsin B, human recombinant
7580-1000
EUR 11739.6

Active Cathepsin B, human recombinant
7580-5
EUR 352.8

Active Cathepsin B, human recombinant
7580-50
EUR 1358.4

Cathepsin K, Active, human recombinant
7600-5
EUR 470.4

Cathepsin K, Active, human recombinant
7600-50
EUR 2734.8

MMP-9, Active, human recombinant
7867-1000
EUR 601.2

MMP-9, Active, human recombinant
7867-500
EUR 398.4

Active BCL2L1 Protein, human recombinant
7885-10
EUR 307.2

Active BCL2L1 Protein, human recombinant
7885-50
EUR 829.2

5-Lipoxygenase, Active, Human Recombinant
P1373-200
EUR 379.2

MMP-9, Active, Human Recombinant
P1567-10 10 µg
EUR 417.6

MMP-9, Active, Human Recombinant
P1567-50 50 µg
EUR 612

Mouse NCOR2 shRNA Plasmid
20-abx972783
  • EUR 961.20
  • EUR 1345.20
  • 150 µg
  • 300 µg

HDAC-1 Blocking Peptide
3601BP-50
EUR 183.6

HDAC-2 Blocking Peptide
3602BP-50
EUR 183.6

HDAC-4 Blocking Peptide
3604BP-50
EUR 183.6

HDAC-5 Blocking Peptide
3605BP-50
EUR 183.6

HDAC-6 Blocking Peptide
3606BP-50
EUR 183.6

HDAC-7 Blocking Peptide
3607BP-50
EUR 183.6

HDAC-8 Blocking Peptide
3608BP-50
EUR 183.6

HDAC-9 Blocking Peptide
3609BP-50
EUR 183.6

HDAC-10 Blocking Peptide
3610BP-50
EUR 183.6

HDAC-11 Blocking Peptide
3611BP-50
EUR 183.6

HDAC 1 Blocking Peptide
33R-10516 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 1 antibody, catalog no. 20R-1661

HDAC 2 Blocking Peptide
33R-10517 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 2 antibody, catalog no. 20R-1662

HDAC 4 Blocking Peptide
33R-10519 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 4 antibody, catalog no. 20R-1664

HDAC 5 Blocking Peptide
33R-10520 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 5 antibody, catalog no. 20R-1666

HDAC 6 Blocking Peptide
33R-10521 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 6 antibody, catalog no. 20R-1667

HDAC 7 Blocking Peptide
33R-10522 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 7 antibody, catalog no. 20R-1668

HDAC 8 Blocking Peptide
33R-10523 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 8 antibody, catalog no. 20R-1669

HDAC 9 Blocking Peptide
33R-10524 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 9 antibody, catalog no. 20R-1670

HDAC 10 Blocking Peptide
33R-10525 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 10 antibody, catalog no. 20R-1671

HDAC 11 Blocking Peptide
33R-10526 50 ug
EUR 418.8
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 11 antibody, catalog no. 20R-1672

HDAC Substrate II, Colorimetric
2395-25
EUR 548.4

HDAC Substrate II, Colorimetric
2395-5
EUR 183.6

AR-42 (HDAC-42)
2716-1
EUR 183.6

AR-42 (HDAC-42)
2716-5
EUR 548.4

DiscoveryPak? HDAC Inhibitor Set
K851-6
EUR 823.2

JAK/HDAC-IN-1
HY-126141 10mM/1mL
EUR 286.8

HDAC Family Antibody Set
K333-11-30
EUR 1488

Trichostatin A (HDAC inhibitor)
SIH-254-1MG 1 mg
EUR 247.2
Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Trichostatin A (HDAC inhibitor)
SIH-254-5MG 5 mg
EUR 735.6
Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)
SIH-255-100MG 100 mg
EUR 111.6
Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)
SIH-255-500MG 500 mg
EUR 152.4
Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Bml-210 (HDAC inhibitor)
SIH-348-25MG 25 mg
EUR 1039.2
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Bml-210 (HDAC inhibitor)
SIH-348-5MG 5 mg
EUR 319.2
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Sodium Valproate (HDAC inhibitor)
SIH-357-5G 5 g
EUR 114
Description: The substance Sodium Valproate is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml Water.

SAHA (Vorinostat) (HDAC inhibitor)
SIH-359-250MG 250 mg
EUR 394.8
Description: The substance SAHA (Vorinostat) is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol.

SAHA (Vorinostat) (HDAC inhibitor)
SIH-359-50MG 50 mg
EUR 153.6
Description: The substance SAHA (Vorinostat) is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol.

MS 275 (HDAC inhibitor)
SIH-416-1MG 1 mg
EUR 205.2
Description: The substance MS 275 is a hdac inhibitor. It is synthetically produced and has a purity of >98.5. The pure substance is off white solid which is soluble in DMSO or methanol..

Human recombinant UBE2D3
6430-3
EUR 438

Human recombinant UBE2L3
6431-3
EUR 438

LIGHT, Human Recombinant
P1291-3
EUR 210

Recombinant Human Mitogen-Activated Protein Kinase 3, Active
7-03937 3µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active
7-03938 10µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active
7-03939 20µg Ask for price

NCOR2 sgRNA CRISPR Lentivector set (Human)
K1400601 3 x 1.0 ug
EUR 406.8

Human HDAC(Histone deacetylase) ELISA Kit
EH4908 96T
EUR 628.92
Description: Method of detection: Double Antibody, Sandwich ELISA;Reacts with: Homo sapiens ;Sensitivity: 0.094 ng/ml

Ncor2 sgRNA CRISPR Lentivector (Mouse) (Target 3)
K4359604 1.0 ug DNA
EUR 184.8

Ncor2 sgRNA CRISPR Lentivector (Rat) (Target 3)
K7301604 1.0 ug DNA
EUR 184.8

NCOR2 3'UTR GFP Stable Cell Line
TU065325 1.0 ml
EUR 1825.2

Ncor2 3'UTR GFP Stable Cell Line
TU263797 1.0 ml Ask for price

Ncor2 3'UTR Luciferase Stable Cell Line
TU113901 1.0 ml Ask for price

Ncor2 3'UTR GFP Stable Cell Line
TU163901 1.0 ml Ask for price

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