DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown

Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis.

Strategies & outcomes: Myeloid particular PHD knockout (PHDko) mice had been obtained through bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown by means of lysozyme M-driven Cre recombinase (PHD2cko). Mice had been fed excessive ldl cholesterol eating regimen for 6-12 weeks to induce atherosclerosis. Aortic root plaque measurement was considerably augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko in comparison with controls, however was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, through the HIF1α/BNIP3 axis. Bulk and single cell RNA knowledge of PHD2cko bone-marrow-derived macrophages (BMDM) and plaque macrophages, respectively, confirmed enhanced HIF1α/BNIP3 signaling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively related to plaque necrotic core measurement, suggesting comparable pro-apoptotic results in human.

Additional, PHD2cko plaques displayed enhanced fibrosis, whereas macrophage collagen breakdown by matrix metalloproteinases, collagen manufacturing and proliferation had been unaltered. As an alternative, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine method. In silico evaluation of macrophage-fibroblast communication predicted SPP1 (osteopontin) signaling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Elevated SPP1 mRNA expression upon PHD2cko was preferentially noticed in foamy plaque macrophages expressing “triggering receptor expressed on myeloid cells-2” (TREM2hi) evidenced by single-cell RNA, however not in neutrophils. This confirmed enhanced fibrotic signaling by PHD2cko macrophages to fibroblasts, in vitro in addition to in vivo.

Conclusion: Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque progress and macrophage apoptosis, whereas PHD2cko macrophages additional activated collagen secretion by fibroblasts in vitro, possible through paracrine SPP1 signaling by means of TREM2hi macrophages.

Translational outlook: This research exhibits that myeloid PHD isoforms PHD2 and PHD3 worsen plaque traits and phenotype, corresponding to plaque measurement, macrophage accumulation, apoptosis, and collagen accumulation in mice. We present each direct results on macrophages and paracrine results of macrophage PHD2 loss on vessel wall fibroblast populations. Broad spectrum-PHD inhibitors, e.g. Roxadustat, are presently being prescribed to power kidney illness sufferers, who’re already in danger for heart problems. When contemplating this research and the pro-fibrotic and pro-apoptotic results we report, broad PHD inhibition might due to this fact be sub-optimal and extra focused PHD inhibition of PHD1 must be thought of.

The results of various temperatures of post-exercise protein-containing drink on gastric motility and power consumption in wholesome younger males 

The current research examined the consequences of various temperatures of protein-containing drink after train on subsequent gastric motility and power consumption in wholesome younger males. Twelve wholesome younger males accomplished three, one-day trials in a random order. In all trials, the topics ran on a treadmill for 30 min at 80% of most coronary heart fee. In train + chilly drink (2 °C) and train + sizzling drink (60 °C) trials, the topics consumed 300 mL of protein-containing drink (0.34 MJ) at 2 °C or 60 °C over a 5-min interval after train. Within the train (i.e., no preload) trial, the topics sat on a chair for five min after train. Then, the topics sat on a chair for 30 min to measure their gastric motility with an ultrasound imaging system in all trials.

Thereafter, the topics consumed a take a look at meal till they felt comfortably full. Vitality consumption within the train + sizzling drink trial was 14 % and 15 % greater than the train (P=0.046, 95% CI: 4.010-482.538) trial and train + chilly drink (P=0.001, 95% CI: 160.089-517.111) trial, respectively. The frequency of the gastric contractions within the train + sizzling drink trial was greater than the train (P=0.023) trial and train + chilly drink (P=0.007) trial. The overall frequency of gastric contractions was positively associated to power consumption (r=0.386, P=0.022). These findings reveal that consuming protein-containing drink after train at 60 °C will increase power consumption and that this improve could also be associated to the modulation of the gastric motility.

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anti- BLOC1S1-Specific antibody

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anti- CAPG-Specific antibody

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anti- CPT1B-specific antibody

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  • IHC: 1:50-1:500
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  • Immunogen: carnitine palmitoyltransferase 1B(muscle)
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anti- CPT1C-specific antibody

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  • Immunogen: cullin 4A
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  • Immunogen: chemokine(C-X-C motif) receptor 3
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anti- CXCR7-Specific antibody

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  • Immunogen: chemokine(C-X-C motif) receptor 7
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anti- CYP1A2-Specific antibody

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  • IHC: 1:100-1:400
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  • IHC: 1:20-1:200
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  • IHC: 1:20-1:200
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  • Immunogen: cytochrome P450, family 4, subfamily F, polypeptide 11
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anti- CYP4Z1-Specific antibody

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  • Immunogen: cytochrome P450, family 4, subfamily Z, polypeptide 1
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anti- DAPK2-Specific antibody

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  • IF: 1:10-1:100
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EUR 505.25
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  • Immunogen: deleted in colorectal carcinoma
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  • Gene ID: 1630
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anti- DGKK-Specific antibody

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EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IF: 1:10-1:100
  • Immunogen: diacylglycerol kinase, kappa
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anti- DLL1-Specific antibody

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EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: delta-like 1(Drosophila)
  • Uniprot ID: O00548
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Description: Antibody raised against DLL1-Specific

anti- DOCK180-Specific antibody

FNab02493 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2400
  • IF: 1:10-1:100
  • Immunogen: dedicator of cytokinesis 1
  • Uniprot ID: Q14185
  • Research Area: Signal Transduction
Description: Antibody raised against DOCK180-Specific

anti- DR5-Specific antibody

FNab02530 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:2000
  • Immunogen: tumor necrosis factor receptor superfamily, member 10b
  • Uniprot ID: O14763
  • Gene ID: 8795
  • Research Area: Immunology, Signal Transduction
Description: Antibody raised against DR5-Specific

anti- EDG7-Specific antibody

FNab02635 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: lysophosphatidic acid receptor 3
  • Uniprot ID: Q9UBY5
  • Research Area: Signal Transduction
Description: Antibody raised against EDG7-Specific

anti- EGFR-Specific antibody

FNab02669 100µg
EUR 505.25
  • Recommended dilution: WB: 1:2000-1:4000
  • IP: 1:500-1:1000
  • IHC: 1:200-1:800
  • IF: 1:50-1:500
  • Immunogen: epidermal growth factor receptor
  • Uniprot ID: P00533
  • Gene ID: 1956
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Cancer, Immunolog
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Description: Antibody raised against EGFR-Specific

anti- EIF2C1-Specific antibody

FNab02697 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: eukaryotic translation initiation factor 2C, 1
  • Uniprot ID: Q9UL18
  • Gene ID: 26523
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against EIF2C1-Specific

anti- EIF2C3-Specific antibody

FNab02698 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: eukaryotic translation initiation factor 2C, 3
  • Uniprot ID: Q9H9G7
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against EIF2C3-Specific

anti- EPHA1-specific antibody

FNab02801 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:50-1:500
  • Immunogen: EPH receptor A1
  • Uniprot ID: P21709
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Description: Antibody raised against EPHA1-specific

anti- EPHA6-Specific antibody

FNab02804 100µg
EUR 505.25
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: EPH receptor A6
  • Uniprot ID: Q9UF33
  • Gene ID: 285220
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Neuroscience
Description: Antibody raised against EPHA6-Specific

anti- FABP7-Specific antibody

FNab02937 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • IHC: 1:50-1:500
  • Immunogen: fatty acid binding protein 7, brain
  • Uniprot ID: O15540
  • Research Area: Signal Transduction, Metabolism, Developmental biology, Neuroscience, Stem Cells
Description: Antibody raised against FABP7-Specific

anti- FANCA-Specific antibody

FNab03004 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: Fanconi anemia, complementation group A
  • Uniprot ID: O15360
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against FANCA-Specific

anti- FcRn-Specific antibody

FNab03063 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: Fc fragment of IgG, receptor, transporter, alpha
  • Uniprot ID: P55899
  • Gene ID: 2217
  • Research Area: Neuroscience
Description: Antibody raised against FcRn-Specific

anti- FGF16-Specific antibody

FNab03091 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: fibroblast growth factor 16
  • Uniprot ID: O43320
  • Research Area: Immunology, Signal Transduction, Metabolism
Description: Antibody raised against FGF16-Specific

anti- FMO2-specific antibody

FNab03169 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: flavin containing monooxygenase 2(non-functional)
  • Uniprot ID: Q99518
  • Gene ID: 2327
  • Research Area: Metabolism
Description: Antibody raised against FMO2-specific

anti- FMO5-specific antibody

FNab03171 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: flavin containing monooxygenase 5
  • Uniprot ID: P49326
  • Research Area: Metabolism
Description: Antibody raised against FMO5-specific

anti- FOXH1-Specific antibody

FNab03196 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: forkhead box H1
  • Uniprot ID: O75593
  • Research Area: Epigenetics, Signal Transduction, Metabolism, Developmental biology, Neuroscience
Description: Antibody raised against FOXH1-Specific

anti- FOXL2-Specific antibody

FNab03199 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: forkhead box L2
  • Uniprot ID: P58012
  • Research Area: Neuroscience, Signal Transduction, Metabolism, Developmental biology
Description: Antibody raised against FOXL2-Specific

anti- GAB3-Specific antibody

FNab03273 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: GRB2-associated binding protein 3
  • Uniprot ID: Q8WWW8
  • Research Area: Signal Transduction, Developmental biology
Description: Antibody raised against GAB3-Specific

anti- GABARAPL1-Specific antibody

FNab03276 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein like 1
  • Uniprot ID: Q9H0R8
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL1-Specific

anti- GABARAPL2-Specific antibody

FNab03278 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GABA(A) receptor-associated protein-like 2
  • Uniprot ID: P60520
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GABARAPL2-Specific

anti- GAC-specific antibody

FNab03290 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:100-1:400
  • Immunogen: glutaminase
  • Uniprot ID: O94925
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against GAC-specific

anti- ACADL-Specific antibody

FNab00064 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: acyl-Coenzyme A dehydrogenase, long chain
  • Uniprot ID: P28330
  • Gene ID: 33
  • Research Area: Metabolism
Description: Antibody raised against ACADL-Specific

anti- ACTA1-Specific antibody

FNab00115 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • Immunogen: actin, alpha 1, skeletal muscle
  • Uniprot ID: P68133
  • Gene ID: 58
  • Research Area: Cardiovascular, Immunology, Cancer, Developmental biology, Neuroscience, Cell Division and Proliferation
Description: Antibody raised against ACTA1-Specific

anti- ADAM17-Specific antibody

FNab00139 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: ADAM metallopeptidase domain 17
  • Uniprot ID: P78536
  • Gene ID: 6868
  • Research Area: Signal Transduction, Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience
Description: Antibody raised against ADAM17-Specific

anti- ADRA1A-Specific antibody

FNab00177 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:500
  • Immunogen: adrenergic, alpha-1A-, receptor
  • Uniprot ID: P35348
  • Gene ID: 148
  • Research Area: Neuroscience, Cardiovascular, Developmental biology, Signal Transduction
Description: Antibody raised against ADRA1A-Specific

anti- ADRA2B-Specific antibody

FNab00179 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:50-1:500
  • Immunogen: adrenergic, alpha-2B-, receptor
  • Uniprot ID: P18089
  • Gene ID: 151
  • Research Area: Signal Transduction
Description: Antibody raised against ADRA2B-Specific

anti- AFF1-Specific antibody

FNab00195 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • IF: 1:50 - 1:100
  • Immunogen: AF4/FMR2 family, member 1
  • Uniprot ID: P51825
  • Gene ID: 4299
  • Research Area: Cancer, Metabolism
Description: Antibody raised against AFF1-Specific

anti- AMPD1-Specific antibody

FNab00370 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • Immunogen: adenosine monophosphate deaminase 1(isoform M)
  • Uniprot ID: P23109
  • Gene ID: 270
  • Research Area: Metabolism
Description: Antibody raised against AMPD1-Specific

anti- ARF5-Specific antibody

FNab00534 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:3000
  • IF: 1:10-1:100
  • Immunogen: ADP-ribosylation factor 5
  • Uniprot ID: P62330
  • Gene ID: 381
  • Research Area: Metabolism
Description: Antibody raised against ARF5-Specific

anti- ARF6-Specific antibody

FNab00535 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:50-1:100
  • IHC: 1:50-1:500
  • Immunogen: ADP-ribosylation factor 6
  • Uniprot ID: P62330
  • Gene ID: 382
  • Research Area: Metabolism
Description: Antibody raised against ARF6-Specific

anti- ARHGEF9-Specific antibody

FNab00565 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: Cdc42 guanine nucleotide exchange factor(GEF) 9
  • Uniprot ID: O43307
  • Gene ID: 23229
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against ARHGEF9-Specific

anti- ARSK-Specific antibody

FNab00613 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: arylsulfatase family, member K
  • Uniprot ID: Q6UWY0
  • Research Area: Metabolism
Description: Antibody raised against ARSK-Specific

anti- TMF1-Specific antibody

FNab08796 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: TATA element modulatory factor 1
  • Uniprot ID: P82094
  • Research Area: Metabolism
Description: Antibody raised against TMF1-Specific

anti- TOP2A-Specific antibody

FNab08868 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: topoisomerase(DNA) II alpha 170kDa
  • Uniprot ID: P11388
  • Research Area: Epigenetics, Cell Division and Proliferation, Metabolism
Description: Antibody raised against TOP2A-Specific

anti- Tuberin-Specific antibody

FNab09101 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200;IF: 1:10-1:100
  • Immunogen: tuberous sclerosis 2
  • Uniprot ID: P49815
  • Gene ID: 7249
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against Tuberin-Specific

anti- TWIST1-specific antibody

FNab09118 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • Immunogen: twist homolog 1
  • Uniprot ID: Q15672
  • Research Area: Epigenetics, Metabolism, Cardiovascular, Developmental biology, Neuroscience, Stem Cells
Description: Antibody raised against TWIST1-specific

anti- UBASH3A-Specific antibody

FNab09150 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IF: 1:10-1:100;IP: 1:200-1:2000
  • Immunogen: ubiquitin associated and SH3 domain containing, A
  • Uniprot ID: P57075
  • Research Area: Metabolism
Description: Antibody raised against UBASH3A-Specific

anti- UBC9-Specific antibody

FNab09159 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200;IF: 1:10-1:100
  • Immunogen: ubiquitin-conjugating enzyme E2I(UBC9 homolog, yeast)
  • Uniprot ID: P63279
  • Research Area: Epigenetics, Metabolism, Developmental biology, Neuroscience, Cell Division an
  • Show more
Description: Antibody raised against UBC9-Specific

anti- UBN1-Specific antibody

FNab09202 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IHC: 1:20-1:200
  • Immunogen: ubinuclein 1
  • Uniprot ID: Q9NPG3
  • Research Area: Metabolism
Description: Antibody raised against UBN1-Specific

anti- UNC5C-Specific antibody

FNab09263 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:5000
  • Immunogen: unc-5 homolog C(C. elegans)
  • Uniprot ID: O95185
  • Research Area: Signal Transduction, Developmental biology
Description: Antibody raised against UNC5C-Specific

anti- UNC5D-Specific antibody

FNab09264 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:2000
  • Immunogen: unc-5 homolog D(C. elegans)
  • Uniprot ID: Q6UXZ4
  • Research Area: Signal Transduction, Developmental biology
Description: Antibody raised against UNC5D-Specific

anti- URB1-Specific antibody

FNab09286 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:2000
  • Immunogen: URB1 ribosome biogenesis 1 homolog(S. cerevisiae)
  • Uniprot ID: O60287
  • Research Area: Metabolism
Description: Antibody raised against URB1-Specific

anti- WASF4-Specific antibody

FNab09469 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000;IF: 1:10-1:100
  • Immunogen: WAS protein family, member 4
  • Uniprot ID: Q8IV90
  • Research Area: Metabolism
Description: Antibody raised against WASF4-Specific

anti- YES1-Specific antibody

FNab09563 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:2000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1
  • Uniprot ID: P07947
  • Research Area: Cancer, Signal Transduction, Metabolism, Developmental biology
Description: Antibody raised against YES1-Specific

anti- ZIC4-Specific antibody

FNab09637 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:2000
  • Immunogen: Zic family member 4
  • Uniprot ID: Q8N9L1
  • Research Area: Neuroscience
Description: Antibody raised against ZIC4-Specific

anti- ZNF600-Specific antibody

FNab09718 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: zinc finger protein 600
  • Uniprot ID: Q6ZNG1
  • Research Area: Metabolism
Description: Antibody raised against ZNF600-Specific

anti- ZNRF2-Specific antibody

FNab09746 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: zinc and ring finger 2
  • Uniprot ID: Q8NHG8
  • Research Area: Neuroscience, Metabolism, Epigenetics
Description: Antibody raised against ZNRF2-Specific

anti- TUBB3 specific antibody

FNab09890 100µg
EUR 548.75
  • Recommended dilution: WB: 1:5000-1:50000
  • IHC: 1:50-1:500
  • Immunogen: AS160
  • Uniprot ID: Q13509
  • Gene ID: 10381
  • Research Area: Signal Transduction
Description: Antibody raised against TUBB3 specific

anti- GLI3-Specific antibody

FNab10099 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:50 - 1:500
  • Immunogen: GLI family zinc finger 3
  • Uniprot ID: P10071
  • Gene ID: 2737
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against GLI3-Specific

anti- HIP1-Specific antibody

FNab03870 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: huntingtin interacting protein 1
  • Uniprot ID: O00291
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against HIP1-Specific

anti- HMMR-Specific antibody

FNab03936 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: hyaluronan-mediated motility receptor(RHAMM)
  • Uniprot ID: O75330
  • Research Area: Immunology
Description: Antibody raised against HMMR-Specific

anti- HNRNPUL2-Specific antibody

FNab03961 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:50-1:500
  • Immunogen: heterogeneous nuclear ribonucleoprotein U-like 2
  • Uniprot ID: Q1KMD3
  • Research Area: Metabolism
Description: Antibody raised against HNRNPUL2-Specific

anti- HRAS-Specific antibody

FNab04008 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IP:1:1000-1:6000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: v-Ha-ras Harvey rat sarcoma viral oncogene homolog
  • Uniprot ID: P01112
  • Research Area: Cancer, Immunology, Signal Transduction, Cell Division and Proli
  • Show more
Description: Antibody raised against HRAS-Specific

anti- HSPG2-Specific antibody

FNab04063 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • Immunogen: heparan sulfate proteoglycan 2
  • Uniprot ID: P98160
  • Research Area: Immunology, Cardiovascular, Signal Transduction
Description: Antibody raised against HSPG2-Specific

anti- IFITM1-Specific antibody

FNab04141 100µg
EUR 585
  • Recommended dilution: WB: 1:5000 - 1:50000
  • IHC: 1:200 - 1:1000
  • IP: 1:500 - 1:1000
  • Immunogen: interferon induced transmembrane protein 1(9-27)
  • Uniprot ID: P13164
  • Research Area: Immunology, Signal Transduction
Description: Antibody raised against IFITM1-Specific

anti- IFITM2-specific antibody

FNab04143 100µg
EUR 585
  • Recommended dilution: WB: 1:500 - 1:2000
  • Immunogen: interferon induced transmembrane protein 2
  • Uniprot ID: Q01629
  • Research Area: Immunology
Description: Antibody raised against IFITM2-specific

anti- IGF1B-Specific antibody

FNab04169 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:20 - 1:200
  • Immunogen: insulin-like growth factor 1(somatomedin C)
  • Uniprot ID: P05019
  • Gene ID: 3479
  • Research Area: Signal Transduction, Metabolism, Immunology, Developmental biology, Neuroscience
Description: Antibody raised against IGF1B-Specific

anti- IGF2R-Specific antibody

FNab04174 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: insulin-like growth factor 2 receptor
  • Uniprot ID: P11717
  • Research Area: Cancer, Immunology, Signal Transduction
Description: Antibody raised against IGF2R-Specific

anti- ING1-specific antibody

FNab04309 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000;IP: 1:200-1:1000
  • Immunogen: inhibitor of growth family, member 1
  • Uniprot ID: Q9UK53
  • Research Area: Cancer
Description: Antibody raised against ING1-specific

anti- ING3-specific antibody

FNab04312 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2400
  • Immunogen: inhibitor of growth family, member 3
  • Uniprot ID: Q9NXR8
  • Research Area: Cancer, Metabolism
Description: Antibody raised against ING3-specific

anti- ING4-specific antibody

FNab04314 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: inhibitor of growth family, member 4
  • Uniprot ID: Q9UNL4
  • Research Area: Cancer, Metabolism
Description: Antibody raised against ING4-specific

anti- ITPR1-specific antibody

FNab04425 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • Immunogen: inositol 1,4,5-triphosphate receptor, type 1
  • Uniprot ID: Q14643
  • Research Area: Neuroscience, Immunology, Signal Transduction
Description: Antibody raised against ITPR1-specific

anti- KCNB1-Specific antibody

FNab04480 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: potassium voltage-gated channel, Shab-related subfamily, member 1
  • Uniprot ID: Q13303
  • Research Area: Neuroscience
Description: Antibody raised against KCNB1-Specific

anti- KGA-Specific antibody

FNab04520 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:20-1:400
  • Immunogen: glutaminase
  • Uniprot ID: O94925
  • Research Area: Neuroscience, Metabolism
Description: Antibody raised against KGA-Specific

anti- KISS1R-Specific antibody

FNab04593 100µg
EUR 585
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • IF: 1:50 - 1:200
  • Immunogen: KISS1 receptor
  • Uniprot ID: Q969F8
  • Gene ID: 84634
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against KISS1R-Specific

anti- KLHL14-Specific antibody

FNab04614 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: kelch-like 14(Drosophila)
  • Uniprot ID: Q9P2G3
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against KLHL14-Specific

anti- KRT10-specific antibody

FNab04649 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: keratin 10
  • Uniprot ID: P13645
  • Research Area: Signal Transduction
Description: Antibody raised against KRT10-specific

anti- Kv1.4-Specific antibody

FNab04664 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:2000
  • Immunogen: potassium voltage-gated channel, shaker-related subfamily, member 4
  • Uniprot ID: P22459
  • Research Area: Neuroscience
Description: Antibody raised against Kv1.4-Specific

anti- LAMC3-Specific antibody

FNab04680 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500 - 1:1000
  • Immunogen: laminin, gamma 3
  • Uniprot ID: Q9Y6N6
  • Research Area: Signal Transduction
Description: Antibody raised against LAMC3-Specific

anti- LATS2-Specific antibody

FNab04709 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: LATS, large tumor suppressor, homolog 2
  • Uniprot ID: Q9NRM7
  • Gene ID: 26524
  • Research Area: Signal Transduction, Metabolism
Description: Antibody raised against LATS2-Specific

anti- LC3A-Specific antibody

FNab04719 100µg
EUR 505.25
  • Recommended dilution: WB: 1:1000-1:4000
  • IF: 1:10-1:100
  • Immunogen: microtubule-associated protein 1 light chain 3 alpha
  • Uniprot ID: Q9H492
  • Gene ID: 84557
  • Research Area: Neuroscience, Cardiovascular, Metabolism
Description: Antibody raised against LC3A-Specific

anti- LC3B-Specific antibody

FNab04720 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • IF: 1:50 - 1:200
  • Immunogen: microtubule-associated protein 1 light chain 3 beta
  • Uniprot ID: Q9GZQ8
  • Gene ID: 81631
  • Research Area: Neuroscience, Cardiovascular, Metabolism
Description: Antibody raised against LC3B-Specific

anti- LDHA-Specific antibody

FNab04737 100µg
EUR 548.75
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:1000-1:4000
  • IHC: 1:20-1:200
  • IF: 1:20-1:200
  • Immunogen: lactate dehydrogenase A
  • Uniprot ID: P00338
  • Gene ID: 3939
  • Research Area: Cardiovascular, Metabolism
Description: Antibody raised against LDHA-Specific

anti- LDHB-Specific antibody

FNab04739 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:100-1:400
  • IF: 1:10-1:100
  • Immunogen: lactate dehydrogenase B
  • Uniprot ID: P07195
  • Research Area: Cancer, Metabolism
Description: Antibody raised against LDHB-Specific

anti- LDHC-Specific antibody

FNab04740 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: lactate dehydrogenase C
  • Uniprot ID: P07864
  • Research Area: Metabolism
Description: Antibody raised against LDHC-Specific

anti- Lin28A-specific antibody

FNab04784 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: lin-28 homolog(C. elegans)
  • Uniprot ID: Q9H9Z2
  • Research Area: Neuroscience, Stem Cells, Metabolism, Epigenetics
Description: Antibody raised against Lin28A-specific

anti- Lin28B-specific antibody

FNab04786 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: lin-28 homolog B(C. elegans)
  • Uniprot ID: Q6ZN17
  • Research Area: Epigenetics, Stem Cells, Metabolism
Description: Antibody raised against Lin28B-specific

anti- LRP2-Specific antibody

FNab04847 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:100-1:400
  • Immunogen: low density lipoprotein-related protein 2
  • Uniprot ID: P98164
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against LRP2-Specific

anti- MAS1L-Specific antibody

FNab05020 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • IF: 1:10-1:100
  • Immunogen: MAS1 oncogene-like
  • Uniprot ID: P35410
  • Research Area: Cancer, Signal Transduction
Description: Antibody raised against MAS1L-Specific

anti- MCL1L-specific antibody

FNab05054 100µg
EUR 505.25
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: myeloid cell leukemia sequence 1(BCL2-related)
  • Uniprot ID: Q07820
  • Research Area: Stem Cells, Cancer, Metabolism, Developmental biology
Description: Antibody raised against MCL1L-specific

anti- MDM1-Specific antibody

FNab05076 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: Mdm1 nuclear protein homolog(Mouse)
  • Uniprot ID: Q8TC05
  • Research Area: Epigenetics, Metabolism, Immunology, Cancer, Cell Division and Proliferation
Description: Antibody raised against MDM1-Specific

anti- MEF2C-Specific antibody

FNab05107 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: myocyte enhancer factor 2C
  • Uniprot ID: Q06413
  • Research Area: Metabolism, Cardiovascular, Immunology, Developmental biology, Neuroscience, Stem Cells
Description: Antibody raised against MEF2C-Specific

anti- MYH10-Specific antibody

FNab05472 100µg
EUR 505.25
  • Recommended dilution: WB: 1:1000-1:4000
  • IP: 1:500-1:2000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: myosin, heavy chain 10, non-muscle
  • Uniprot ID: P35580
  • Research Area: Cancer, Immunology, Developmental biology
Description: Antibody raised against MYH10-Specific

anti- MYH4-Specific antibody

FNab05476 100µg
EUR 548.75
  • Recommended dilution: WB: 1:200-1:1000
  • IHC: 1:20-1:200
  • Immunogen: myosin, heavy chain 4, skeletal muscle
  • Uniprot ID: Q9Y623
  • Gene ID: 4621
  • Research Area: Cardiovascular, Immunology, Developmental biology, Neuroscience, Cell Division and Proliferation
Description: Antibody raised against MYH4-Specific

anti- MYH7-specific antibody

FNab05478 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: myosin, heavy chain 7, cardiac muscle, beta
  • Uniprot ID: P12883
  • Research Area: Cardiovascular, Developmental biology, Neuroscience, Stem Cells, Cell Division and Proliferation
Description: Antibody raised against MYH7-specific

anti- MYOM1-Specific antibody

FNab05516 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: myomesin 1, 185kDa
  • Uniprot ID: P52179
  • Research Area: Neuroscience, Cardiovascular, Developmental biology
Description: Antibody raised against MYOM1-Specific

anti- MYPN-Specific antibody

FNab05525 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: myopalladin
  • Uniprot ID: Q86TC9
  • Research Area: Neuroscience
Description: Antibody raised against MYPN-Specific

anti- MYSM1-Specific antibody

FNab05527 100µg
EUR 585
  • Recommended dilution: WB: 1:300-1:600
  • IHC: 1:20-1:200
  • IF: 1:50-1:500
  • Immunogen: Myb-like, SWIRM and MPN domains 1
  • Uniprot ID: Q5VVJ2
  • Research Area: Metabolism
Description: Antibody raised against MYSM1-Specific

anti- NARFL-Specific antibody

FNab05553 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: nuclear prelamin A recognition factor-like
  • Uniprot ID: Q9H6Q4
  • Research Area: Signal Transduction, Metabolism, Cell Division and Proliferation
Description: Antibody raised against NARFL-Specific

anti- NEB-Specific antibody

FNab05638 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: nebulin
  • Uniprot ID: Q7Z6G3
  • Research Area: Neuroscience
Description: Antibody raised against NEB-Specific

anti- Neogenin-Specific antibody

FNab05662 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: neogenin homolog 1(chicken)
  • Uniprot ID: Q92859
  • Research Area: Signal Transduction, Metabolism, Cancer, Immunology, Developmental biology
Description: Antibody raised against Neogenin-Specific

anti- GATA4-Specific antibody

FNab03363 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: GATA binding protein 4
  • Uniprot ID: P43694
  • Gene ID: 2626
  • Research Area: Epigenetics, Signal Transduction, Metabolism, Cardiovascular, Developmental biology, Stem Cell
  • Show more
Description: Antibody raised against GATA4-Specific

anti- GEFT-Specific antibody

FNab03416 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:3000
  • IP: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: RhoA/RAC/CDC42 exchange factor
  • Uniprot ID: Q86VW2
  • Research Area: Neuroscience, Signal Transduction
Description: Antibody raised against GEFT-Specific

anti- GLI2-Specific antibody

FNab03477 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: GLI-Kruppel family member GLI2
  • Uniprot ID: P10070
  • Research Area: Stem Cells
Description: Antibody raised against GLI2-Specific

anti- GLI3-Specific antibody

FNab03478 100µg
EUR 505.25
  • Recommended dilution: WB: 1:200-1:1000
  • IP: 1:200-1:1000
  • IHC: 1:20-1:200
  • IF: 1:10-1:100
  • Immunogen: GLI family zinc finger 3
  • Uniprot ID: P10071
  • Gene ID: 2737
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against GLI3-Specific

anti- GPR101-Specific antibody

FNab03587 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: G protein-coupled receptor 101
  • Uniprot ID: Q96P66
  • Research Area: Signal Transduction
Description: Antibody raised against GPR101-Specific

anti- GPR123-Specific antibody

FNab03592 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: G protein-coupled receptor 123
  • Uniprot ID: Q86SQ6
  • Research Area: Signal Transduction
Description: Antibody raised against GPR123-Specific

anti- GPR139-Specific antibody

FNab03596 100µg
EUR 505.25
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: G protein-coupled receptor 139
  • Uniprot ID: Q6DWJ6
  • Research Area: Signal Transduction
Description: Antibody raised against GPR139-Specific

anti- GPRASP1-Specific antibody

FNab03612 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:3000
  • IHC: 1:20-1:200
  • Immunogen: G protein-coupled receptor associated sorting protein 1
  • Uniprot ID: Q5JY77
  • Research Area: Signal Transduction
Description: Antibody raised against GPRASP1-Specific

anti- GPRIN3-Specific antibody

FNab03616 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • IF: 1:10-1:100
  • Immunogen: GPRIN family member 3
  • Uniprot ID: Q6ZVF9
  • Research Area: Neuroscience
Description: Antibody raised against GPRIN3-Specific

anti- HBA1-Specific antibody

FNab03767 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:50-1:500
  • Immunogen: hemoglobin, alpha 1
  • Uniprot ID: P69905
  • Research Area: Immunology
Description: Antibody raised against HBA1-Specific

anti- HBG1-Specific antibody

FNab03772 100µg
EUR 585
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: hemoglobin, gamma A
  • Uniprot ID: P69891
  • Gene ID: 3047
  • Research Area: Immunology, Cardiovascular
Description: Antibody raised against HBG1-Specific

anti- HBM-Specific antibody

FNab03773 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: hemoglobin, mu
  • Uniprot ID: Q6B0K9
  • Research Area: Immunology
Description: Antibody raised against HBM-Specific

anti- HBQ1-Specific antibody

FNab03776 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • Immunogen: hemoglobin, theta 1
  • Uniprot ID: P09105
  • Research Area: Immunology, Cardiovascular
Description: Antibody raised against HBQ1-Specific

anti- HBZ-Specific antibody

FNab03780 100µg
EUR 585
  • Recommended dilution: WB: 1:1000-1:4000
  • Immunogen: hemoglobin, zeta
  • Uniprot ID: P02008
  • Research Area: Immunology
Description: Antibody raised against HBZ-Specific

anti- HDAC1-specific antibody

FNab03795 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IF: 1:10-1:100
  • Immunogen: histone deacetylase 1
  • Uniprot ID: Q13547
  • Research Area: Epigenetics, Cardiovascular, Metabolism
Description: Antibody raised against HDAC1-specific

anti- HDAC2-specific antibody

FNab03797 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IF: 1:10-1:100
  • IHC: 1:20-1:200
  • Immunogen: histone deacetylase 2
  • Uniprot ID: Q92769
  • Research Area: Epigenetics, Cardiovascular, Metabolism
Description: Antibody raised against HDAC2-specific

anti- HDAC3-specific antibody

FNab03799 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: histone deacetylase 3
  • Uniprot ID: O15379
  • Research Area: Epigenetics, Cardiovascular, Metabolism
Description: Antibody raised against HDAC3-specific

anti- HDAC4-specific antibody

FNab03801 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: histone deacetylase 4
  • Uniprot ID: P56524
  • Research Area: Epigenetics, Cardiovascular, Metabolism, Developmental biology
Description: Antibody raised against HDAC4-specific

anti- HDAC5-specific antibody

FNab03802 100µg
EUR 585
  • Recommended dilution: WB: 1:200-1:1000
  • IF: 1:50-1:500
  • IHC: 1:20-1:200
  • Immunogen: histone deacetylase 5
  • Uniprot ID: Q9UQL6
  • Gene ID: 51020
  • Research Area: Epigenetics, Cardiovascular, Metabolism
Description: Antibody raised against HDAC5-specific

anti- HDAC6-specific antibody

FNab03804 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500 - 1:2000
  • IHC: 1:50 - 1:200
  • Immunogen: histone deacetylase 6
  • Uniprot ID: Q9UBN7
  • Gene ID: 10013
  • Research Area: Epigenetics, Metabolism
Description: Antibody raised against HDAC6-specific

anti- neurturin-Specific antibody

FNab05683 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: neurturin
  • Uniprot ID: Q99748
  • Research Area: Neuroscience, Signal Transduction, Developmental biology
Description: Antibody raised against neurturin-Specific

anti- NFIX-Specific antibody

FNab05701 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: nuclear factor I/X(CCAAT-binding transcription factor)
  • Uniprot ID: Q14938
  • Research Area: Neuroscience, Epigenetics
Description: Antibody raised against NFIX-Specific

anti- NOX3-Specific antibody

FNab05805 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: NADPH oxidase 3
  • Uniprot ID: Q9HBY0
  • Research Area: Metabolism
Description: Antibody raised against NOX3-Specific

anti- OCT2-Specific antibody

FNab05962 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:200
  • Immunogen: POU class 2 homeobox 2
  • Uniprot ID: P09086
  • Gene ID: 5452
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against OCT2-Specific

anti- Oct6-Specific antibody

FNab05965 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • Immunogen: POU class 3 homeobox 1
  • Uniprot ID: Q86VW1
  • Research Area: Neuroscience, Metabolism, Developmental biology
Description: Antibody raised against Oct6-Specific

anti- ORM2-Specific antibody

FNab06014 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:5000
  • IF: 1:50-1:500
  • Immunogen: orosomucoid 2
  • Uniprot ID: P19652
  • Research Area: Cardiovascular
Description: Antibody raised against ORM2-Specific

anti- PACS2-Specific antibody

FNab06099 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:50-1:500
  • IF: 1:10-1:100
  • Immunogen: phosphofurin acidic cluster sorting protein 2
  • Uniprot ID: Q86VP3
  • Research Area: Cell Division and Proliferation
Description: Antibody raised against PACS2-Specific

anti- Palladin-Specific antibody

FNab06127 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IP: 1:200-1:1000
  • Immunogen: palladin, cytoskeletal associated protein
  • Uniprot ID: Q8WX93
  • Research Area: Neuroscience, Immunology
Description: Antibody raised against Palladin-Specific

anti- PAX1-Specific antibody

FNab06167 100µg
EUR 548.75
  • Recommended dilution: WB: 1:500-1:2000
  • Immunogen: paired box 1
  • Uniprot ID: P15863
  • Research Area: Metabolism, Developmental biology
Description: Antibody raised against PAX1-Specific

anti- PAX8-Specific antibody

FNab06177 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: paired box 8
  • Uniprot ID: Q06710
  • Research Area: Cancer, Immunology, Metabolism, Developmental biology
Description: Antibody raised against PAX8-Specific

anti- persephin-Specific antibody

FNab06323 100µg
EUR 585
  • Recommended dilution: WB: 1:500-1:1000
  • IHC: 1:20-1:200
  • Immunogen: persephin
  • Uniprot ID: O60542
  • Research Area: Neuroscience, Developmental biology
Description: Antibody raised against persephin-Specific

anti- PFKFB3-Specific antibody

FNab06339 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:50-1:200
  • IF: 1:20-1:200
  • Immunogen: 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3
  • Uniprot ID: Q16875
  • Gene ID: 5209
  • Research Area: Metabolism
Description: Antibody raised against PFKFB3-Specific

Induction of protecting immune responses in opposition to a deadly Zika virus problem post-vaccination with a twin serotype of recombinant vesicular stomatitis virus carrying the genetically modified Zika virus E protein gene

The event of a vaccine to forestall Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine in opposition to ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. We’ve employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a kind 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.

Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced robust protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.

Chilly-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β manufacturing 

Background: Gout is an autoinflammatory illness pushed by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β manufacturing relies on inflammasome activation, which requires a priming sign, adopted by an activating sign. The cold-inducible RNA-binding protein (CIRP) has been not too long ago recognized as a damage-associated molecular sample (DAMP). On this research, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1β secretion utilizing human neutrophils. 

Strategies: Human neutrophils had been stimulated by MSU within the presence or absence of CIRP priming to find out NLRP3 inflammasome activation and subsequent caspase-1 activation and IL-1β manufacturing. Mobile supernatants had been analyzed by enzyme-linked immunosorbent assay (ELISA) to find out the presence of IL-1β or caspase-1 (p20). The mobile supernatants and lysates had been additionally analyzed by immunoblotting utilizing anti-cleaved IL-1β or anti-cleaved caspase-1 antibodies.

Outcomes: Neither CIRP nor MSU stimulation alone induced ample IL-1β secretion from neutrophils. Nevertheless, MSU stimulation induced IL-1β secretion from CIRP-primed neutrophils in a dose-dependent method. This MSU-induced IL-1β secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1β (p17), which was inhibited by the pretreatment of MCC950, a selected inhibitor for NLRP3. Moreover, cleaved caspase-1 was induced within the mobile lysates of CIRP/MSU-treated neutrophils. Moreover, CIRP stimulation induced the protein expression of pro-IL-1β in neutrophils. 

Conclusions: Our knowledge point out that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1β induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. We suggest that CIRP acts as an necessary proinflammatory stimulant that primes and prompts inflammasome and pro-IL-1β processing in response to uric acid in innate immune cells.

Active Human Caspases Group I, Active Human

K241-3-25
EUR 370

HDAC-8, human recombinant

7618-100
EUR 588

HDAC-8, human recombinant

7618-1000
EUR 4345

HDAC-8, human recombinant

7618-20
EUR 262

Anti-active Caspase-3 Rabbit Monoclonal Antibody

M00334-3 100ug/vial
EUR 397
Description: Anti-active Caspase-3 Rabbit Monoclonal Antibody tested for IF, IHC, ICC, WB in Human

CST3 Mouse, Cystatin-C, Recombinant Protein Mouse Active

PROTP21460-3 Regular: 10ug
EUR 317
Description: CST3 Mouse produced in Sf9 Insect cells is a single, glycosylated polypeptide chain containing 126 amino acids (21-140 a.a.) and having a molecular mass of 14.2kDa (Molecular size on SDS-PAGE will appear at approximately 13.5-18kDa).;CST3 is expressed with a 6 amino acid His tag at C-Terminus and purified by proprietary chromatographic techniques.

HDAC 3 antibody

20R-1663 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 3 antibody

HDAC-IN-3

HY-19772 50mg
EUR 2116

NCOR2/ Rat NCOR2 ELISA Kit

ELA-E11288r 96 Tests
EUR 886

HDAC 3 Blocking Peptide

33R-10518 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 3 antibody, catalog no. 20R-1663

HDAC-3 Blocking Peptide

3603BP-50
EUR 153

Recombinant Human MMP-3 Protein

PROTP08254-3 10ug
EUR 317
Description: Matrix metalloproteinases (MMPs) are a family of endoproteases that require zinc and calcium for expressing catalytic activity. These enzymes play a central role in the maintenance and remodeling of the extracellular matrix. Elevated expression of their activity, caused either by up-regulation of their expression or down-regulation of their cognate inhibitors, has been implicated in various degenerative disorders, including arthritis, cardiovascular disease, skeletal growth-plate disorders, and cancer metastasis. MMP-3 degrades fibronectin, laminin, collagens III, IV, and X, and cartilage proteoglycans. Recombinant human MMP-3 is a 42.8 kDa protein containing the entire catalytic N-terminal domain and the C-terminal domain (378 amino acids).

NCOR2 antibody

70R-18789 50 ul
EUR 435
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 Antibody

43109-100ul 100ul
EUR 252

NCOR2 Antibody

1-CSB-PA080039
  • EUR 222.00
  • EUR 195.00
  • 100ug
  • 50ug
  • Form: Liquid
  • Buffer: Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human. This antibody is Unconjugated. Tested in the following application: IHC, IF, ELISA;IHC:1/100-1/300.IF:1/200-1/1000.ELISA:1/20000

NCOR2 Antibody

DF8896 200ul
EUR 304
Description: NCOR2 Antibody detects endogenous levels of total NCOR2.

NCOR2 Antibody

1-CSB-PA015548GA01HU
  • EUR 597.00
  • EUR 333.00
  • 150ul
  • 50ul
  • Form: Liquid
  • Buffer: PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20℃, Avoid freeze / thaw cycles. Antigen Affinity purified
Description: A polyclonal antibody against NCOR2. Recognizes NCOR2 from Human, Mouse, Rat. This antibody is Unconjugated. Tested in the following application: ELISA, WB

NCOR2 antibody

70R-32241 100 ug
EUR 327
Description: Rabbit polyclonal NCOR2 antibody

NCOR2 siRNA

20-abx925532
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

NCOR2 siRNA

20-abx925533
  • EUR 551.00
  • EUR 732.00
  • 15 nmol
  • 30 nmol
  • Shipped within 5-10 working days.

NCOR2 Antibody

ABD8896 100 ug
EUR 438

NCOR2 antibody

PAab10069 100 ug
EUR 386

anti-NCOR2

YF-PA25381 50 ul
EUR 334
Description: Mouse polyclonal to NCOR2

HDAC ELISA KIT|Human

EF010966 96 Tests
EUR 689

IL-3 Interleukin-3 Human Recombinant Protein, His Tag

PROTP08700-3 Regular: 50ug
EUR 317
Description: Interleukin-3 Human Recombinant produced in E.Coli is single, a non-glycosylated, Polypeptide chain containing 154 amino acids fragment (20-152) and having a total molecular mass of 17.3kDa and fused with a 20 aa N-terminal His tag. ;The IL3 His is purified by proprietary chromatographic techniques.

Human NCOR2 ELISA Kit

ELA-E0334h 96 Tests
EUR 824

NCOR2 ELISA KIT|Human

EF000574 96 Tests
EUR 689

Human NCOR2 shRNA Plasmid

20-abx956396
  • EUR 801.00
  • EUR 1121.00
  • 150 µg
  • 300 µg
  • Shipped within 15-20 working days.

NCOR2 sgRNA CRISPR Lentivector (Human) (Target 3)

K1400604 1.0 ug DNA
EUR 154

PRMT1, human recombinant (Active)

4865-10
EUR 153

PRMT1, human recombinant (Active)

4865-1000
EUR 3834

PRMT1, human recombinant (Active)

4865-50
EUR 392

Active AHCY, human recombinant

7527-10
EUR 262

Active AHCY, human recombinant

7527-1000
EUR 5482

Active AHCY, human recombinant

7527-50
EUR 479

Active Recombinant Human CETP

7606-100
EUR 805

Active Recombinant Human CETP

7606-1000
EUR 4345

Active Recombinant Human CETP

7606-20
EUR 262

Active SIRT2, human recombinant

7698-10
EUR 262

Active SIRT2, human recombinant

7698-1000
EUR 4394

Active SIRT2, human recombinant

7698-50
EUR 457

Active SIRT7, human recombinant

7846-10
EUR 218

Active SIRT7, human recombinant

7846-50
EUR 588

Irisin, Active, human recombinant

7852-10
EUR 370

Irisin, Active, human recombinant

7852-50
EUR 1077

HER2, Active, Human Recombinant

8011-5
EUR 240

HER2, Active, Human Recombinant

8011-50
EUR 1132

GAPDH, Active, human recombinant

P1100-10
EUR 142

GAPDH, Active, human recombinant

P1100-50
EUR 392

HDAC Substrate, Colorimetric

2207-100
EUR 300

HDAC Substrate, Colorimetric

2207-25
EUR 126

HDAC Substrate, Fluorogenic

2396-25
EUR 512

HDAC Substrate, Fluorogenic

2396-5
EUR 175

HDAC 1 antibody

20R-1661 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 1 antibody

HDAC 2 antibody

20R-1662 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 2 antibody

HDAC 4 antibody

20R-1664 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 4 antibody

20R-1665 100 ug
EUR 673
Description: Rabbit polyclonal HDAC 4 antibody

HDAC 5 antibody

20R-1666 100 ug
EUR 662
Description: Rabbit polyclonal HDAC 5 antibody

HDAC 6 antibody

20R-1667 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 6 antibody

HDAC 7 antibody

20R-1668 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 7 antibody

HDAC 8 antibody

20R-1669 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 8 antibody

HDAC 9 antibody

20R-1670 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 9 antibody

HDAC 10 antibody

20R-1671 100 ug
EUR 629
Description: Rabbit polyclonal HDAC 10 antibody

HDAC 11 antibody

20R-1672 100 ug
EUR 651
Description: Rabbit polyclonal HDAC 11 antibody

HDAC Assay Kit

55R-1371 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Assay Kit

55R-1372 100 assays
EUR 673
Description: Assay Kit for detection of HDAC in the research laboratory

HDAC Set I

A9906-1 1 Set
EUR 154

HDAC-IN-7

HY-13592 10mM/1mL
EUR 215

Apicidin (HDAC inhibitor)

SIH-346-1MG 1 mg
EUR 136
  • Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1? protein levels and transcriptional activity in human and mouse t
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Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

Apicidin (HDAC inhibitor)

SIH-346-5MG 5 mg
EUR 340
  • Cyclopeptide inhibitor of histone deactylases (HDACs). Inhibits HeLa cell proliferation (IC50=50-100 nM) and induces reversible transcriptional activation of p21 (WAF1). Decreases HIF1? protein levels and transcriptional activity in human and mouse t
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Description: The substance Apicidin is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 10 mg/ml DMSO or 100% Ethanol.

HPA (HDAC inhibitor)

SIH-356-10MG 10 mg
EUR 128
  • Histone deacetylase (HDAC) inhibitor, IC50=13 µM Histone deacetylase (HDAC) inhibitor, IC50=13 µM
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

HPA (HDAC inhibitor)

SIH-356-50MG 50 mg
EUR 226
  • Histone deacetylase (HDAC) inhibitor, IC50=13 µM Histone deacetylase (HDAC) inhibitor, IC50=13 µM
Description: The substance HPA is a hdac inhibitor. It is synthetically produced and has a purity of >97%. The pure substance is colorless oil which is soluble in 25 mg/ml DMSO or 25 mg/ml Ethanol.

PLGF3 Human, Placenta Growth Factor-3 Human Recombinant Protein, sf9

PROTP49763-3 Regular: 25ug
EUR 317
Description: PLGF3 Human Recombinant produced in Spodoptera frugiperda is a glycosylated homodimer containing 2 chains of 203 amino acids (Leu19-Arg221) and having a molecular mass of 58kDa.;The PLGF-3 is purified by proprietary chromatographic techniques.

NCOR2 Blocking Peptide

DF8896-BP 1mg
EUR 195

NCOR2 Conjugated Antibody

C43109 100ul
EUR 397

NCOR2 Rabbit pAb

A8388-100ul 100 ul
EUR 308

NCOR2 Rabbit pAb

A8388-200ul 200 ul
EUR 459

NCOR2 Rabbit pAb

A8388-20ul 20 ul
EUR 183

NCOR2 Rabbit pAb

A8388-50ul 50 ul
EUR 223

anti- NCOR2 antibody

FNab10069 100µg
EUR 548.75
  • Recommended dilution: IHC: 1:20-1:200
  • Immunogen: nuclear receptor co-repressor 2
  • Uniprot ID: Q9Y618
  • Gene ID: 9612
  • Research Area: Metabolism
Description: Antibody raised against NCOR2

anti- NCOR2 antibody

FNab05594 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500 - 1:2000
  • IF: 1:50 - 1:100
  • Immunogen: nuclear receptor co-repressor 2
  • Uniprot ID: Q9Y618
  • Gene ID: 9612
  • Research Area: Metabolism
Description: Antibody raised against NCOR2

Anti-NCOR2 antibody

PAab05594 100 ug
EUR 355

Anti-NCOR2 antibody

STJ110686 100 µl
EUR 277
Description: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

TGF-b-3 Transforming Growth Factor-Beta 3 Human Recombinant Protein, Plant

PROTP10600-3 Regular: 5ug
EUR 317
Description: TGFB3 Human Recombinant produced in plant is a disulfide-linked homodimeric, glycosylated, polypeptide chain containing 118 amino acids and having a molecular mass of 27.2kDa. ;The TGFB3 is fused to 6xHis tag at N-terminus and purified by standard chromatographic techniques.

NCOR2 ORF Vector (Human) (pORF)

ORF025977 1.0 ug DNA
EUR 2730

NCOR2 ELISA Kit (Human) (OKEH04298)

OKEH04298 96 Wells
EUR 662
Description: Description of target: This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.;Species reactivity: Human;Application: ;Assay info: Assay Methodology: Quantitative Sandwich ELISA;Sensitivity: 100 pg/mL

Human recombinant UBE2D3

6430-3
EUR 365

Human recombinant UBE2L3

6431-3
EUR 365

LIGHT, Human Recombinant

P1291-3
EUR 175

Recombinant Human Assembly Protein Complex 3

7-04360 2µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04361 10µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04362 1mg Ask for price

Recombinant Human Activin-A Active

7-00004 1ug Ask for price

Recombinant Human Activin-A Active

7-00005 5ug Ask for price

Recombinant Human Activin-A Active

7-00006 100µg Ask for price

Recombinant Human Activin-B Active

7-00010 1ug Ask for price

Recombinant Human Activin-B Active

7-00011 5ug Ask for price

Recombinant Human Activin-B Active

7-00012 100µg Ask for price

Active Cathepsin S, human recombinant

7526-10
EUR 338

Active Cathepsin S, human recombinant

7526-50
EUR 1126

Active Cathepsin S, human recombinant

7526-500
EUR 9130

Active Cathepsin B, human recombinant

7580-1000
EUR 9783

Active Cathepsin B, human recombinant

7580-5
EUR 294

Active Cathepsin B, human recombinant

7580-50
EUR 1132

Cathepsin K, Active, human recombinant

7600-5
EUR 392

Cathepsin K, Active, human recombinant

7600-50
EUR 2279

MMP-9, Active, human recombinant

7867-1000
EUR 501

MMP-9, Active, human recombinant

7867-500
EUR 332

Active BCL2L1 Protein, human recombinant

7885-10
EUR 256

Active BCL2L1 Protein, human recombinant

7885-50
EUR 691

MMP-14, Active, Human Recombinant

8009-10
EUR 316

MMP-14, Active, Human Recombinant

8009-50
EUR 805

Active Cathepsin D, Human Recombinant

9229-10
EUR 245

Active Cathepsin D, Human Recombinant

9229-100
EUR 1132

Active Cathepsin D, Human Recombinant

9229-50
EUR 735

5-Lipoxygenase, Active, Human Recombinant

P1373-200
EUR 316

MMP-9, Active, Human Recombinant

P1567-10 10 µg
EUR 348

MMP-9, Active, Human Recombinant

P1567-50 50 µg
EUR 510

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03937 3µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03938 10µg Ask for price

Recombinant Human Mitogen-Activated Protein Kinase 3, Active

7-03939 20µg Ask for price

HDAC Substrate II, Colorimetric

2395-25
EUR 457

HDAC Substrate II, Colorimetric

2395-5
EUR 153

AR-42 (HDAC-42)

2716-1
EUR 153

AR-42 (HDAC-42)

2716-5
EUR 457

HDAC 1 Blocking Peptide

33R-10516 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 1 antibody, catalog no. 20R-1661

HDAC 2 Blocking Peptide

33R-10517 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 2 antibody, catalog no. 20R-1662

HDAC 4 Blocking Peptide

33R-10519 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 4 antibody, catalog no. 20R-1664

HDAC 5 Blocking Peptide

33R-10520 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 5 antibody, catalog no. 20R-1666

HDAC 6 Blocking Peptide

33R-10521 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 6 antibody, catalog no. 20R-1667

HDAC 7 Blocking Peptide

33R-10522 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 7 antibody, catalog no. 20R-1668

HDAC 8 Blocking Peptide

33R-10523 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 8 antibody, catalog no. 20R-1669

HDAC 9 Blocking Peptide

33R-10524 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 9 antibody, catalog no. 20R-1670

HDAC 10 Blocking Peptide

33R-10525 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 10 antibody, catalog no. 20R-1671

HDAC 11 Blocking Peptide

33R-10526 50 ug
EUR 349
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of HDAC 11 antibody, catalog no. 20R-1672

HDAC-1 Blocking Peptide

3601BP-50
EUR 153

HDAC-2 Blocking Peptide

3602BP-50
EUR 153

HDAC-4 Blocking Peptide

3604BP-50
EUR 153

HDAC-5 Blocking Peptide

3605BP-50
EUR 153

HDAC-6 Blocking Peptide

3606BP-50
EUR 153

HDAC-7 Blocking Peptide

3607BP-50
EUR 153

HDAC-8 Blocking Peptide

3608BP-50
EUR 153

HDAC-9 Blocking Peptide

3609BP-50
EUR 153

HDAC-10 Blocking Peptide

3610BP-50
EUR 153

HDAC-11 Blocking Peptide

3611BP-50
EUR 153

JAK/HDAC-IN-1

HY-126141 10mM/1mL
EUR 239

DiscoveryPak? HDAC Inhibitor Set

K851-6
EUR 686

HDAC Family Antibody Set

K333-11-30
EUR 1240

Trichostatin A (HDAC inhibitor)

SIH-254-1MG 1 mg
EUR 206
  • Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression
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Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Trichostatin A (HDAC inhibitor)

SIH-254-5MG 5 mg
EUR 613
  • Trichostatin A is an antifungal and selectively inhibits the class I and II mammalian histon deacetlyase families of enzymes (1). TSA inhibits the eukayotic cell cycle during the beginning of the growth stage. It can be used to alter gene expression
  • Show more
Description: The substance Trichostatin A is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is beige solid which is soluble to 10 mM in ethanol and to 50 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)

SIH-255-100MG 100 mg
EUR 93
  • Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration an
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Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Phenylbutyrate Na (HDAC inhibitor)

SIH-255-500MG 500 mg
EUR 127
  • Sodium phenylbutyrate is metabolized in the human body by beta-oxidation to phenylacetate, which is then conjugated with glutamine to phenylacetylglutamine, which is eliminated with urine (1). It inhibits cell proliferation, invasion and migration an
  • Show more
Description: The substance Phenylbutyrate Na is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble to 1100 mM in water and 100 mM in DMSO.

Bml-210 (HDAC inhibitor)

SIH-348-25MG 25 mg
EUR 866
  • A novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 µM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines.
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Bml-210 (HDAC inhibitor)

SIH-348-5MG 5 mg
EUR 266
  • A novel non-hydroxamic acid HDAC inhibitor. IC50=5-10 µM (HeLa nuclear extract). Induces growth inhibition, proapoptotic and differentiation effects on human leukemia cell lines.
Description: The substance Bml-210 is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is tan solid which is soluble in 25 mg/ml DMSO or 10 mg/ml Ethanol.

Sodium Valproate (HDAC inhibitor)

SIH-357-5G 5 g
EUR 95
  • Histone deacetylase inhibitor (IC50=400 µM). Demonstrates neuroprotective, anticancer and anti-inflammatory activity. Inhibits A? production and neuritic plaque formation in Alzheimer's mouse models. Clinically useful anticonvulsant.
Description: The substance Sodium Valproate is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml Water.

SAHA (Vorinostat) (HDAC inhibitor)

SIH-359-250MG 250 mg
EUR 329
  • Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
Description: The substance SAHA (Vorinostat) is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol.

SAHA (Vorinostat) (HDAC inhibitor)

SIH-359-50MG 50 mg
EUR 128
  • Potent and selective histone deacetylase inhibitor. Induces apoptosis in a variety of tumor cell lines. Synergizes with kinase inhibitors to kill CNS tumor cells. Cell permeable.
Description: The substance SAHA (Vorinostat) is a hdac inhibitor. It is synthetically produced and has a purity of >98%. The pure substance is white solid which is soluble in 50 mg/ml DMSO, or 2 mg/ml Ethanol.

MS 275 (HDAC inhibitor)

SIH-416-1MG 1 mg
EUR 171
  • MS 275, also referred to as Entinostat, is a benzamide histone deacetylase inhibitor. It preferentially inhibits HDAC1 and HDAC3. It is currently undergoing several clinical trials for the treatment of Hodgkin's lymphoma, advanced breast cancer, and
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Description: The substance MS 275 is a hdac inhibitor. It is synthetically produced and has a purity of >98.5. The pure substance is off white solid which is soluble in DMSO or methanol..

Active Blocker 3

abx090803-01g 0.1 g
EUR 411
  • Shipped within 5-10 working days.

Caspase-3, active

RA15046 50 ug
EUR 383

ANGPTL3 (17-460)Human Angiopoietin-like Protein 3 (17-460 a.a.) Human Recombinant Protein

PROTQ9Y5C1-3 Regular: 10ug
EUR 317
Description: ANGPTL3 produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 453 amino acids (17-460 a.a.) and having a molecular mass of 52.9kDa (Migrates at 25-70kDa on SDS-PAGE under reducing conditions). 

Human recombinant UBE2R1 (CDC34)

6436-3
EUR 365

Human recombinant UBE2R2 (Ubc3B)

6437-3
EUR 392

Human recombinant UBE2E2 (UbcH8)

6438-3
EUR 392

sIL-4R?, Human Recombinant

P1287-3
EUR 175

Recombinant Human Sox2 Protein

PROTP48431-3 25ug
EUR 317
Description: Sox2, also known as sex determining region Y (SRY)-box 2, belongs to a diverse family of structurally-related transcription factors whose primary structure contains a 79-residue DNA-binding domain, called high mobility group (HMG) box. It plays an essential role in maintaining the pluripotency of embryonic stem cells (ESC) and determination of cell fate. Microarray analysis showed that Sox2 regulates the expression of multiple genes involved in embryonic development including FGF-4, YES1 and ZFP206. Sox2 acts as a transcriptional activator after forming a ternary complex with Oct3/4 and a conserved non-coding DNA sequence (CNS1) located approximately 2 kb upstream of the RAX promoter. The introduction of Sox2, Oct4, Myc, and Klf4, into human dermal fibroblasts isolated from a skin biopsy of a healthy research fellow was sufficient to confer a pluripotent state upon the fibroblast genome. The reprogrammed cells thus obtained resemble ESC in morphology, gene expression, and in the capacity to form teratomas in immune-deficient mice. Recombinant human Sox2 is a 34.3 kDa protein containing 317 amino-acid residues.

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