DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown

Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis.

Strategies & outcomes: Myeloid particular PHD knockout (PHDko) mice had been obtained through bone marrow transplantation (PHD1ko, PHD3ko) or conditional knockdown by means of lysozyme M-driven Cre recombinase (PHD2cko). Mice had been fed excessive ldl cholesterol eating regimen for 6-12 weeks to induce atherosclerosis. Aortic root plaque measurement was considerably augmented 2.6-fold in PHD2cko, and 1.4-fold in PHD3ko in comparison with controls, however was unchanged in PHD1ko mice. Macrophage apoptosis was promoted in PHD2cko and PHD3ko mice in vitro and in vivo, through the HIF1α/BNIP3 axis. Bulk and single cell RNA knowledge of PHD2cko bone-marrow-derived macrophages (BMDM) and plaque macrophages, respectively, confirmed enhanced HIF1α/BNIP3 signaling, which was validated in vitro by siRNA silencing. Human plaque BNIP3 mRNA was positively related to plaque necrotic core measurement, suggesting comparable pro-apoptotic results in human.

Additional, PHD2cko plaques displayed enhanced fibrosis, whereas macrophage collagen breakdown by matrix metalloproteinases, collagen manufacturing and proliferation had been unaltered. As an alternative, PHD2cko BMDMs enhanced fibroblast collagen secretion in a paracrine method. In silico evaluation of macrophage-fibroblast communication predicted SPP1 (osteopontin) signaling as regulator, which was corroborated by enhanced plaque SPP1 protein in vivo. Elevated SPP1 mRNA expression upon PHD2cko was preferentially noticed in foamy plaque macrophages expressing “triggering receptor expressed on myeloid cells-2” (TREM2hi) evidenced by single-cell RNA, however not in neutrophils. This confirmed enhanced fibrotic signaling by PHD2cko macrophages to fibroblasts, in vitro in addition to in vivo.

Conclusion: Myeloid PHD2cko and PHD3ko enhanced atherosclerotic plaque progress and macrophage apoptosis, whereas PHD2cko macrophages additional activated collagen secretion by fibroblasts in vitro, possible through paracrine SPP1 signaling by means of TREM2hi macrophages.

Translational outlook: This research exhibits that myeloid PHD isoforms PHD2 and PHD3 worsen plaque traits and phenotype, corresponding to plaque measurement, macrophage accumulation, apoptosis, and collagen accumulation in mice. We present each direct results on macrophages and paracrine results of macrophage PHD2 loss on vessel wall fibroblast populations. Broad spectrum-PHD inhibitors, e.g. Roxadustat, are presently being prescribed to power kidney illness sufferers, who’re already in danger for heart problems. When contemplating this research and the pro-fibrotic and pro-apoptotic results we report, broad PHD inhibition might due to this fact be sub-optimal and extra focused PHD inhibition of PHD1 must be thought of.

The results of various temperatures of post-exercise protein-containing drink on gastric motility and power consumption in wholesome younger males 

The current research examined the consequences of various temperatures of protein-containing drink after train on subsequent gastric motility and power consumption in wholesome younger males. Twelve wholesome younger males accomplished three, one-day trials in a random order. In all trials, the topics ran on a treadmill for 30 min at 80% of most coronary heart fee. In train + chilly drink (2 °C) and train + sizzling drink (60 °C) trials, the topics consumed 300 mL of protein-containing drink (0.34 MJ) at 2 °C or 60 °C over a 5-min interval after train. Within the train (i.e., no preload) trial, the topics sat on a chair for five min after train. Then, the topics sat on a chair for 30 min to measure their gastric motility with an ultrasound imaging system in all trials.

Thereafter, the topics consumed a take a look at meal till they felt comfortably full. Vitality consumption within the train + sizzling drink trial was 14 % and 15 % greater than the train (P=0.046, 95% CI: 4.010-482.538) trial and train + chilly drink (P=0.001, 95% CI: 160.089-517.111) trial, respectively. The frequency of the gastric contractions within the train + sizzling drink trial was greater than the train (P=0.023) trial and train + chilly drink (P=0.007) trial. The overall frequency of gastric contractions was positively associated to power consumption (r=0.386, P=0.022). These findings reveal that consuming protein-containing drink after train at 60 °C will increase power consumption and that this improve could also be associated to the modulation of the gastric motility.

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Description: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

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Description: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

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Description: LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.

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  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 1 (GAS1) Antibody (HRP)

20-abx335868
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 6 (GAS6) Antibody (HRP)

20-abx335871
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 2 (GAS2) Antibody (HRP)

20-abx303936
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 7 (GAS7) Antibody (FITC)

20-abx316891
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 1 (GAS1) Antibody (FITC)

20-abx335869
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 6 (GAS6) Antibody (FITC)

20-abx335872
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 2 (GAS2) Antibody (FITC)

20-abx303937
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Goat Anti-Human IgG F(ab')2 fragment specific (adsorbed with bovine, horse, mouse serum proteins)

10115-UL 0.5 mg
EUR 270

anti- SCN9A/Nav1.7-Specific antibody

FNab07646 100µg
EUR 702
Description: Antibody raised against SCN9A/Nav1.7-Specific

anti- Claudin 4-specific antibody

FNab01739 100µg
EUR 606.3
Description: Antibody raised against Claudin 4-specific

anti- Claudin 9-specific antibody

FNab01741 100µg
EUR 606.3
Description: Antibody raised against Claudin 9-specific

Growth Arrest Specific Protein 7 (GAS7) Antibody (Biotin)

20-abx316892
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 1 (GAS1) Antibody (Biotin)

20-abx335870
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 6 (GAS6) Antibody (Biotin)

20-abx335873
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

Growth Arrest Specific Protein 6 (GAS6) Antibody (Biotin)

20-abx271947
  • EUR 510.00
  • EUR 276.00
  • EUR 1429.20
  • EUR 693.60
  • EUR 393.60
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Growth Arrest Specific Protein 2 (GAS2) Antibody (Biotin)

20-abx303938
  • EUR 493.20
  • EUR 2214.00
  • EUR 718.80
  • EUR 218.40
  • EUR 360.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug

anti- fibrillin 2-Specific antibody

FNab03116 100µg
EUR 606.3
Description: Antibody raised against fibrillin 2-Specific

Anti-Claudin 4-specific antibody

PAab01739 100 ug
EUR 426

Anti-Claudin 9-specific antibody

PAab01741 100 ug
EUR 426

Anti-SCN9A/Nav1.7-Specific antibody

PAab07646 100 ug
EUR 494.4

Anti-GAPDH (Human Specific) antibody

STJ99065 200 µl
EUR 236.4
Description: Mouse monoclonal to GAPDH (Human Specific).

anti-Growth Arrest Specific Protein 7

YF-PA15672 50 ul
EUR 435.6
Description: Mouse polyclonal to Growth Arrest Specific Protein 7

anti-Growth Arrest Specific Protein 7

YF-PA15673 50 ug
EUR 435.6
Description: Mouse polyclonal to Growth Arrest Specific Protein 7

Anti-Actin, muscle specific antibody

STJ190001 200 µl
EUR 236.4
Description: Unconjugated Mouse monoclonal to Actin, muscle specific (AS1A20)

Anti-fibrillin 2-Specific antibody

PAab03116 100 ug
EUR 426

anti- Cytokeratin 1-specific antibody

FNab02211 100µg
EUR 658.5
Description: Antibody raised against Cytokeratin 1-specific

anti- Cytokeratin 7-specific antibody

FNab02219 100µg
EUR 658.5
Description: Antibody raised against Cytokeratin 7-specific

anti- Cytokeratin 7-specific antibody

FNab02220 100µg
EUR 702
Description: Antibody raised against Cytokeratin 7-specific

Anti-Myeloid Specific Antigen antibody

STJ16100989 100 µg
EUR 424.8

Anti-Myeloid Specific Antigen antibody

STJ16100158 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100170 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100171 100 µg
EUR 466.8

Anti-Myeloid Specific Antigen antibody

STJ16100172 100 µg
EUR 466.8

anti- Cytokeratin 17-Specific antibody

FNab02203 100µg
EUR 606.3
Description: Antibody raised against Cytokeratin 17-Specific

anti- Cytokeratin 19-specific antibody

FNab02210 100µg
EUR 702
Description: Antibody raised against Cytokeratin 19-specific

Anti-Prostate Specific Antigen antibody

STJ16100961 1 mL
EUR 577.2

anti- TGF-beta 2-Specific antibody

FNab08639 100µg
EUR 658.5
Description: Antibody raised against TGF-beta 2-Specific

Anti-Cytokeratin 1-specific antibody

PAab02211 100 ug
EUR 463.2

Anti-Cytokeratin 7-specific antibody

PAab02219 100 ug
EUR 463.2

Anti-Cytokeratin 7-specific antibody

PAab02220 100 ug
EUR 494.4

Marginal Zone B And B1 Cell Specific Protein (MZB1) Antibody

abx235530-100ug 100 ug
EUR 661.2

Marginal Zone B And B1 Cell Specific Protein (MZB1) Antibody

20-abx323202
  • EUR 376.80
  • EUR 292.80
  • 100 ug
  • 50 ug

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat)

4-PAC573Ra01
  • EUR 310.80
  • EUR 3249.60
  • EUR 804.00
  • EUR 393.60
  • EUR 262.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1)

anti- Thrombospondin 3-Specific antibody

FNab08675 100µg
EUR 658.5
Description: Antibody raised against Thrombospondin 3-Specific

Anti-Cytokeratin 13-Specific antibody

PAab02194 100 ug
EUR 426

Anti-Cytokeratin 17-Specific antibody

PAab02203 100 ug
EUR 426

Anti-Cytokeratin 19-specific antibody

PAab02210 100 ug
EUR 494.4

Anti-Hepatocyte Specific Antigen antibody

STJ16100376 1 mL
EUR 954

Placenta Specific Protein 9 (PLAC9) Monoclonal Antibody (Human)

4-MAQ741Hu21
  • EUR 324.00
  • EUR 3454.80
  • EUR 850.80
  • EUR 411.60
  • EUR 268.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Placenta Specific Protein 9 (PLAC9)

Structure Specific Recognition Protein 1 Antibody

20-abx115877
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Anti-TGF-beta 2-Specific antibody

PAab08639 100 ug
EUR 463.2

Anti-Growth Arrest Specific Protein 7 (1H3)

YF-MA16401 100 ug
EUR 435.6
Description: Mouse monoclonal to Growth Arrest Specific Protein 7

Kv1.4-Specific Antibody

abx234664-100ug 100 ug
EUR 577.2

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Mouse)

4-PAC573Mu01
  • EUR 301.20
  • EUR 3091.20
  • EUR 768.00
  • EUR 379.20
  • EUR 258.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Lymphocyte Specific Protein 1 (LSP1)

Goat Milk Proteins Sample Diluent

F243A 1000 ml
EUR 678
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-100 100 ml
EUR 308.4
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Goat Milk Proteins Sample Diluent

F243A-500 500 ml
EUR 493.2
Description: Goat Milk Proteins Sample Diluent by Cygnus Technologies is available in Europe via Gentaur.

Anti-Human Specific GAPDH mAb antibody

STJ11100959 100 µl
EUR 332.4
Description: This gene encodes a member of the glyceraldehyde-3-phosphate dehydrogenase protein family. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. The product of this gene catalyzes an important energy-yielding step in carbohydrate metabolism, the reversible oxidative phosphorylation of glyceraldehyde-3-phosphate in the presence of inorganic phosphate and nicotinamide adenine dinucleotide (NAD). The encoded protein has additionally been identified to have uracil DNA glycosylase activity in the nucleus. Also, this protein contains a peptide that has antimicrobial activity against E. coli, P. aeruginosa, and C. albicans. Studies of a similar protein in mouse have assigned a variety of additional functions including nitrosylation of nuclear proteins, the regulation of mRNA stability, and acting as a transferrin receptor on the cell surface of macrophage. Many pseudogenes similar to this locus are present in the human genome. Alternative splicing results in multiple transcript variants.

Anti-Thrombospondin 3-Specific antibody

PAab08675 100 ug
EUR 463.2

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat), PE

4-PAC573Ra01-PE
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with PE.

Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody (Rat)

4-PAA204Ra01
  • EUR 291.60
  • EUR 2948.40
  • EUR 735.60
  • EUR 366.00
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Growth Arrest Specific Protein 6 (GAS6)

Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody (Rat)

4-PAA204Ra02
  • EUR 291.60
  • EUR 2948.40
  • EUR 735.60
  • EUR 366.00
  • EUR 254.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Growth Arrest Specific Protein 6 (GAS6)

TUBB3 specific antibody

PAab09890 100 ug
EUR 463.2

Anti-Actin, Muscle Specific (MSA) antibody

STJ180000 0.1 ml
EUR 254.4

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx232285-100ug 100 ug
EUR 610.8

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

abx232286-100ug 100 ug
EUR 577.2

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

20-abx242438
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

20-abx242444
  • EUR 493.20
  • EUR 360.00
  • 100 ul
  • 50 ul

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

20-abx225140
  • EUR 444.00
  • EUR 727.20
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 50 ul

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx219380-100ug 100 ug
EUR 526.8

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

20-abx141699
  • EUR 444.00
  • EUR 727.20
  • EUR 360.00
  • 100 ul
  • 200 ul
  • 50 ul

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx412503-01mg 0.1 mg
EUR 961.2

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

20-abx111958
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

20-abx111959
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

20-abx128508
  • EUR 477.60
  • EUR 159.60
  • EUR 1312.80
  • EUR 644.40
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

20-abx130944
  • EUR 493.20
  • EUR 159.60
  • EUR 1362.00
  • EUR 661.20
  • EUR 376.80
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx432057-200ul 200 ul
EUR 460.8

Damage Specific DNA Binding Protein 2 (DDB2) Antibody

20-abx001528
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

20-abx002127
  • EUR 493.20
  • EUR 710.40
  • EUR 218.40
  • EUR 376.80
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx159468-100ul 100 ul
EUR 560.4

Damage Specific DNA Binding Protein 1 (DDB1) Antibody

abx159469-100ul 100 ul
EUR 560.4

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat), APC

4-PAC573Ra01-APC
  • EUR 436.80
  • EUR 4254.00
  • EUR 1176.00
  • EUR 560.40
  • EUR 272.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with APC.

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat), Cy3

4-PAC573Ra01-Cy3
  • EUR 532.80
  • EUR 5622.00
  • EUR 1518.00
  • EUR 697.20
  • EUR 313.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with Cy3.

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat), HRP

4-PAC573Ra01-HRP
  • EUR 398.40
  • EUR 3706.80
  • EUR 1039.20
  • EUR 505.20
  • EUR 255.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with HRP.

Placenta Specific Protein 9 (PLAC9) Monoclonal Antibody (Human), PE

4-MAQ741Hu21-PE
  • EUR 388.80
  • EUR 3651.60
  • EUR 1020.00
  • EUR 494.40
  • EUR 248.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Placenta Specific Protein 9 (PLAC9). This antibody is labeled with PE.

anti- smooth muscle actin specific antibody

FNab08038 100µg
EUR 606.3
Description: Antibody raised against smooth muscle actin specific

Smad Specific E3 Ubiquitin Protein Ligase 1 Antibody

20-abx115603
  • EUR 878.40
  • EUR 477.60
  • 150 ul
  • 50 ul

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Mouse), PE

4-PAC573Mu01-PE
  • EUR 361.20
  • EUR 3254.40
  • EUR 921.60
  • EUR 454.80
  • EUR 236.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with PE.

Lymphocyte Specific Protein 1 (LSP1) Polyclonal Antibody (Rat), FITC

4-PAC573Ra01-FITC
  • EUR 373.20
  • EUR 3427.20
  • EUR 964.80
  • EUR 471.60
  • EUR 242.40
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Rat Lymphocyte Specific Protein 1 (LSP1). This antibody is labeled with FITC.

Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody (Human)

4-PAA204Hu01
  • EUR 278.40
  • EUR 2742.00
  • EUR 688.80
  • EUR 346.80
  • EUR 249.60
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Human Growth Arrest Specific Protein 6 (GAS6)

Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody (Mouse)

4-PAA204Mu01
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Growth Arrest Specific Protein 6 (GAS6)

Growth Arrest Specific Protein 6 (GAS6) Polyclonal Antibody (Mouse)

4-PAA204Mu02
  • EUR 283.20
  • EUR 2805.60
  • EUR 703.20
  • EUR 352.80
  • EUR 250.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Rabbit polyclonal antibody against Mouse Growth Arrest Specific Protein 6 (GAS6)

Placenta Specific Protein 9 (PLAC9) Monoclonal Antibody (Human), APC

4-MAQ741Hu21-APC
  • EUR 456.00
  • EUR 4534.80
  • EUR 1245.60
  • EUR 588.00
  • EUR 280.80
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Placenta Specific Protein 9 (PLAC9). This antibody is labeled with APC.

Placenta Specific Protein 9 (PLAC9) Monoclonal Antibody (Human), Cy3

4-MAQ741Hu21-Cy3
  • EUR 558.00
  • EUR 5996.40
  • EUR 1611.60
  • EUR 734.40
  • EUR 325.20
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Placenta Specific Protein 9 (PLAC9). This antibody is labeled with Cy3.

Placenta Specific Protein 9 (PLAC9) Monoclonal Antibody (Human), HRP

4-MAQ741Hu21-HRP
  • EUR 415.20
  • EUR 3949.20
  • EUR 1099.20
  • EUR 529.20
  • EUR 264.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
Description: A Mouse monoclonal antibody against Human Placenta Specific Protein 9 (PLAC9). This antibody is labeled with HRP.

Induction of protecting immune responses in opposition to a deadly Zika virus problem post-vaccination with a twin serotype of recombinant vesicular stomatitis virus carrying the genetically modified Zika virus E protein gene

The event of a vaccine to forestall Zika virus (ZIKV) an infection has been one of many priorities in infectious illness analysis lately. There have been quite a few makes an attempt to develop an efficient vaccine in opposition to ZIKV. It’s crucial to decide on the most secure and the best ZIKV vaccine from all candidate vaccines to manage this an infection globally. We’ve employed a twin serotype of prime-boost recombinant vesicular stomatitis virus (VSV) vaccine technique, to develop a ZIKV vaccine candidate, utilizing a kind 1 IFN-receptor knock-out (Ifnar -/-) mouse mannequin for problem research.

Prime vaccination with an attenuated recombinant VSV Indiana serotype (rVSVInd) carrying a genetically modified ZIKV envelope (E) protein gene adopted by enhance vaccination with attenuated recombinant VSV New Jersey serotype (rVSVNJ) carrying the identical E gene induced sturdy adaptive immune responses. Particularly, rVSV carrying the ZIKV E gene with the honeybee melittin sign peptide (msp) on the N terminus and VSV G protein transmembrane area and cytoplasmic tail (Gtc) on the C terminus of the E gene induced robust protecting immune responses. This vaccine routine induced extremely potent neutralizing antibodies and T cell responses within the absence of an adjuvant and guarded Ifnar -/- mice from a deadly dose of the ZIKV problem.

Chilly-inducible RNA-binding protein (CIRP) potentiates uric acid-induced IL-1β manufacturing 

Background: Gout is an autoinflammatory illness pushed by interleukin-1 (IL-1) induction in response to uric acid crystals. IL-1β manufacturing relies on inflammasome activation, which requires a priming sign, adopted by an activating sign. The cold-inducible RNA-binding protein (CIRP) has been not too long ago recognized as a damage-associated molecular sample (DAMP). On this research, we evaluated the roles of CIRP in monosodium urate (MSU)-mediated IL-1β secretion utilizing human neutrophils. 

Strategies: Human neutrophils had been stimulated by MSU within the presence or absence of CIRP priming to find out NLRP3 inflammasome activation and subsequent caspase-1 activation and IL-1β manufacturing. Mobile supernatants had been analyzed by enzyme-linked immunosorbent assay (ELISA) to find out the presence of IL-1β or caspase-1 (p20). The mobile supernatants and lysates had been additionally analyzed by immunoblotting utilizing anti-cleaved IL-1β or anti-cleaved caspase-1 antibodies.

Outcomes: Neither CIRP nor MSU stimulation alone induced ample IL-1β secretion from neutrophils. Nevertheless, MSU stimulation induced IL-1β secretion from CIRP-primed neutrophils in a dose-dependent method. This MSU-induced IL-1β secretion from CIRP-primed neutrophils was accompanied by the induction of cleaved IL-1β (p17), which was inhibited by the pretreatment of MCC950, a selected inhibitor for NLRP3. Moreover, cleaved caspase-1 was induced within the mobile lysates of CIRP/MSU-treated neutrophils. Moreover, CIRP stimulation induced the protein expression of pro-IL-1β in neutrophils. 

Conclusions: Our knowledge point out that CIRP, an endogenous stress molecule, triggers uric acid-induced mature IL-1β induction as a priming stimulus for NLRP3 inflammasome in human neutrophils. We suggest that CIRP acts as an necessary proinflammatory stimulant that primes and prompts inflammasome and pro-IL-1β processing in response to uric acid in innate immune cells.

Recombinant Human Actin Related Protein 2/3 Complex, Subunit 5

7-04404 1mg Ask for price

Human CellExp? HDAC11, Human Recombinant, Active

P1267-50 each
EUR 535.2

Assembly Protein Complex 3 Human (Recombinant)

22061133-1 2 µg
EUR 137.27

ARPC2 Actin Related Protein 2/3 Complex, Subunit 2 Human Recombinant Protein

PROTO15144 Regular: 10ug
EUR 380.4
Description: ARPC2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 323 amino acids (1-300a.a) and having a molecular mass of 36.7kDa. ARPC2 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ARPC5 Actin Related Protein 2/3 Complex, Subunit 5 Human Recombinant Protein

PROTO15511 Regular: 20ug
EUR 380.4
Description: ARPC5 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 171 amino acids (1-151 a.a.) and having a molecular mass of 18.4kDa. ;The ARPC5 is purified by proprietary chromatographic techniques.

Human CellExp? HDAC6, Human Recombinant, Active

P1265-50 each
EUR 535.2

Human CellExp? HDAC8, Human Recombinant, Active

P1266-50 each
EUR 535.2

Recombinant Human Assembly Protein Complex 3

7-04360 2µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04361 10µg Ask for price

Recombinant Human Assembly Protein Complex 3

7-04362 1mg Ask for price

ASCC1 Activating Signal Cointegrator 1 Complex Subunit 1 Human Recombinant Protein

PROTQ8N9N2 Regular: 10ug
EUR 380.4
Description: ASCC1 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 380 amino acids (1-357) and having a molecular mass of 43.6 kDa.;ASCC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

SNAPC1 Small Nuclear RNA Activating Complex, Polypeptide 1 Human Recombinant Protein

PROTQ16533 Regular: 20ug
EUR 380.4
Description: SNAPC1 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 391 amino acids (1-368 a.a) and having a molecular mass of 45.4kDa.;SNAPC1 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Active Recombinant Human IL-3 Protein

RP01362 500μg
EUR 52

Active Recombinant Human IGFBP-3 Protein

RP01363 100μg
EUR 42.25

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-10ug

QP8439-ec-10ug 10ug
EUR 240

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-1mg

QP8439-ec-1mg 1mg
EUR 1958.4

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-50ug

QP8439-ec-50ug 50ug
EUR 315.6

THOC7 THO Complex 7 Human Recombinant Protein

PROTQ6I9Y2 Regular: 10ug
EUR 380.4
Description: THOC7 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 227 amino acids (1-204 a.a) and having a molecular mass of 26.1kDa.THOC7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-100ug

QP8439-ec-100ug 100ug
EUR 489.6

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-200ug

QP8439-ec-200ug 200ug
EUR 760.8

Recombinant Human Actin-related protein 2/ 3 complex subunit 3 Protein, GST, E.coli-500ug

QP8439-ec-500ug 500ug
EUR 1272

Assembly Protein Complex 2 Human (Recombinant)

22061132-1 2 µg
EUR 137.27

Recombinant human GATOR complex protein MIOS

P1240 100ug Ask for price
Description: Recombinant protein for human GATOR complex protein MIOS

HDAC-3, human recombinant

7613-1000 each
EUR 1227.6

HDAC-3, human recombinant

7613-250 each
EUR 444

Recombinant Human Assembly Protein Complex 2

7-04357 2µg Ask for price

Recombinant Human Assembly Protein Complex 2

7-04358 10µg Ask for price

Recombinant Human Assembly Protein Complex 2

7-04359 1mg Ask for price

Recombinant human GATOR complex protein WDR24

P1241 100ug Ask for price
Description: Recombinant protein for human GATOR complex protein WDR24

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-10ug

QP8041-ec-10ug 10ug
EUR 240

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-1mg

QP8041-ec-1mg 1mg
EUR 1958.4

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-50ug

QP8041-ec-50ug 50ug
EUR 315.6

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-10ug

QP8442-ec-10ug 10ug
EUR 240

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-1mg

QP8442-ec-1mg 1mg
EUR 1958.4

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-50ug

QP8442-ec-50ug 50ug
EUR 315.6

Activin-A Human Recombinant Protein, Active

PROTP08476-2 Regular: 10ug
EUR 380.4
Description: Active form Activin-A Human Recombinant produced in e.coli is a homodimeric, non-glycosylated, polypeptide chain containing 2 x 117 amino acids and having a molecular weight of 26.2kDa.;The Active form Activin-A is purified by standard chromatographic techniques.

Activin-B Human Recombinant Protein, Active

PROTP09529 Regular: 10ug
EUR 380.4
Description: Activin B human Recombinant produced in Nicotiana benthamiana plant is a beta-B single chain (aa 293-406) containing 123 amino acids (molecular formula C615H910N178O177S12). Activin B is fused to a 10-His-tag at the N-terminal having the total molecular mass of 14kDa and purified by standard chromatographic techniques.

Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4)

4-RPJ599Hu01
  • EUR 590.94
  • EUR 282.00
  • EUR 1886.02
  • EUR 708.67
  • EUR 1297.34
  • EUR 470.40
  • EUR 4535.04
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Actin Related Protein 2/3 Complex Subunit 4 expressed in: E.coli

Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4)

4-RPJ599Mu01
  • EUR 603.84
  • EUR 285.60
  • EUR 1934.40
  • EUR 724.80
  • EUR 1329.60
  • EUR 480.00
  • EUR 4656.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Mouse Actin Related Protein 2/3 Complex Subunit 4 expressed in: E.coli

Recombinant Actin Related Protein 2/3 Complex Subunit 4 (ARPC4)

4-RPJ599Ra01
  • EUR 636.10
  • EUR 294.00
  • EUR 2055.36
  • EUR 765.12
  • EUR 1410.24
  • EUR 501.60
  • EUR 4958.40
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Rat Actin Related Protein 2/3 Complex Subunit 4 expressed in: E.coli

Recombinant Actin Related Protein 2/3 Complex Subunit 2 (ARPC2)

4-RPJ601Hu01
  • EUR 601.69
  • EUR 284.40
  • EUR 1926.34
  • EUR 722.11
  • EUR 1324.22
  • EUR 477.60
  • EUR 4635.84
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
Description: Recombinant Human Actin Related Protein 2/3 Complex Subunit 2 expressed in: E.coli

Active Recombinant Human EGF Protein

RP01502 10μg
EUR 104

Active Recombinant Human APP Protein

RP01699 10μg
EUR 162.5

Active Recombinant Human CD47 Protein

RP01306 10μg
EUR 91

Active Recombinant Human CD19 Protein

RP01307 10μg
EUR 191.75

Active Recombinant Human GDNF Protein

RP01313 100μg
EUR 61.75

Active Recombinant Human TET2 Protein

RP01335LQ 10μg
EUR 162.5

Active Recombinant Human CD52 Protein

RP01429 100μg
EUR 48.75

Active Recombinant Human TFPI Protein

RP01434 50μg
EUR 48.75

Active Recombinant Human IgG1 Protein

RPT0004 100μg
EUR 39

Active BCL2L1 Protein, human recombinant

7885-10 each
EUR 307.2

Active BCL2L1 Protein, human recombinant

7885-50 each
EUR 829.2

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-100ug

QP8041-ec-100ug 100ug
EUR 489.6

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-200ug

QP8041-ec-200ug 200ug
EUR 760.8

Recombinant Human Actin-related protein 2/ 3 complex subunit 5 Protein, GST, E.coli-500ug

QP8041-ec-500ug 500ug
EUR 1272

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-100ug

QP8442-ec-100ug 100ug
EUR 489.6

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-200ug

QP8442-ec-200ug 200ug
EUR 760.8

Recombinant Human Actin-related protein 2/ 3 complex subunit 2 Protein, GST, E.coli-500ug

QP8442-ec-500ug 500ug
EUR 1272

Active Recombinant Human TYRO3 Protein

RP00203 10μg
EUR 110.5

Active Recombinant Human STAT1 Protein

RP01251 20μg
EUR 539.5

Active Recombinant Human IgG2A Protein

RPT0005 50μg
EUR 195

Human CellExp? HDAC5, Catalytic Domain, Human Recombinant, Active

P1268-50 each
EUR 535.2

Active Recombinant Human IFNAR2 Protein

RP01342 20μg
EUR 91

Recombinant (E.Coli, His-tag) Human Assembly Protein Complex 3

RP-893 10 ug
EUR 343.2

TRAPPC3 Trafficking Protein Particle Complex 3 Human Recombinant Protein

PROTO43617 Regular: 20ug
EUR 380.4
Description: TRAPPC3 Human Recombinant produced in E. coli is a single polypeptide chain containing 200 amino acids (1-180) and having a molecular mass of 22.4kDa.;TRAPPC3 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

GID8 GID Complex Subunit 8 Human Recombinant Protein

PROTQ9NWU2 Regular: 20ug
EUR 380.4
Description: GID8 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 251 amino acids (1-228 a.a) and having a molecular mass of 29.1kDa.;GID8 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

AP3S1 Assembly Protein Complex 3 Subunit-1 Human Recombinant Protein

PROTQ92572 Regular: 20ug
EUR 380.4
Description: AP3S1 Human Recombinant produced in E. coli is a single polypeptide chain containing 213 amino acids (1-193) and having a molecular mass of 23.8 kDa. AP3S1 is fused to 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Active Recombinant Human CD200R1 Protein

RP01365 20μg
EUR 143

Active Recombinant Human IL-5 Protein

RP01316 10μg
EUR 260

Active Recombinant Human IL-4 Protein

RP01597 50μg
EUR 169

Active Recombinant Human IL-9 Protein

RP01649 50μg
EUR 65

Active Recombinant Human IL-9 Protein

RP01686 20μg
EUR 260

Active Recombinant Human IL-6 Protein

RP01688 100μg
EUR 58.5

Active Recombinant Human IL-2 Protein

RP01701 10μg
EUR 97.5

Active Recombinant Human IL-4 Protein

RP01703 20μg
EUR 52

Recombinant human Ragulator complex protein LAMTOR1

P2702 100ug Ask for price
Description: Recombinant protein for human Ragulator complex protein LAMTOR1

Recombinant (E.Coli) Human Assembly Protein Complex 2

RP-892 10 ug
EUR 343.2

Recombinant Human HLA-G Complex Tetramer Protein

RP02685 1000μg
EUR 851.5

Active Recombinant Human IL-15 Protein

RP01257 100μg
EUR 81.25

Active Recombinant Human ACE-2 Protein

RP01266 1mg
EUR 302.25

Active Recombinant Human ACE-2 Protein

RP01275 1mg
EUR 253.5

Active Recombinant Human ACE-2 Protein

RP01277 500μg
EUR 260

Active Recombinant Human IL-21 Protein

RP01312 500μg
EUR 42.25

Active Recombinant Human IL-13 Protein

RP01320 20μg
EUR 143

Active Recombinant Human Dkk-1 Protein

RP01343 100μg
EUR 162.5

Active Recombinant Human FGF-6 Protein

RP01440 20μg
EUR 104

Active Recombinant Human IGF-I Protein

RP01608 50μg
EUR 156

Active Recombinant Human IL-22 Protein

RP01616 100μg
EUR 78

Active Recombinant Human IL-15 Protein

RP01751 10μg
EUR 81.25

Recombinant human Synaptonemal complex central element protein 3

P2248 100ug Ask for price
Description: Recombinant protein for human Synaptonemal complex central element protein 3

Active Recombinant Human IL-12B Protein

RP01288 50μg
EUR 260

Active Recombinant Human TIMP-1 Protein

RP01341 100μg
EUR 97.5

Active Recombinant Human TIMP-2 Protein

RP01370 20μg
EUR 260

Active Recombinant Human IL-23R Protein

RP01376 20μg
EUR 156

Active Recombinant Human BMPR-2 Protein

RP01418 100μg
EUR 26

Active Recombinant Human BMPR-2 Protein

RP01420 10μg
EUR 104

Active Recombinant Human PSA/KLK3 Protein

RP01540 20μg
EUR 61.75

Recombinant Human AFP (HLA-A*02:01) Complex Protein

RP02693 100μg
EUR 1014

SNF8, ESCRT-II Complex Subunit Human Recombinant Protein

PROTQ96H20 Regular: 20ug
EUR 380.4
Description: SNF8 Human Recombinant produced in E. coli is a single polypeptide chain containing 282 amino acids (1-258) and having a molecular mass of 31.4 kDa.;SNF8 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Active Recombinant Human S100-A9 Protein

RP01269 500μg
EUR 175.5

Active Recombinant Human DPP4/CD26 Protein

RP01300LQ 10μg
EUR 260

Active Recombinant Human B29/CD79B Protein

RP01381 100μg
EUR 39

Active Recombinant Human B29/CD79B Protein

RP01464 50μg
EUR 156

MED7 Mediator Complex Subunit 7 Human Recombinant Protein

PROTO43513 Regular: 10ug
EUR 380.4
Description: MED7 Human Recombinant produced in E. coli is a single polypeptide chain containing 256 amino acids (1-233) and having a molecular mass of 29.7 kDa.;MED7 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

MED4 Mediator Complex Subunit 4 Human Recombinant Protein

PROTQ9NPJ6 Regular: 25ug
EUR 380.4
Description: MED4 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 278 amino acids (1-270 a.a.) and having a molecular mass of 30.7kDa._x000D_ MED4 is fused to 8 amino acids His Tag at C-terminus and purified by proprietary chromatographic techniques._x000D_

Recombinant human Nuclear pore complex protein Nup133

P2220 100ug Ask for price
Description: Recombinant protein for human Nuclear pore complex protein Nup133

GINS4 GINS Complex Subunit 4 Protein Human Recombinant Protein

PROTQ9BRT9 Regular: 10ug
EUR 380.4
Description: GINS4 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 243 amino acids (1-223 a.a.) and having a molecular mass of 28.2kDa.GINS4 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Active Recombinant Human ICOS/CD278 Protein

RP01401 20μg
EUR 42.25

MED27 Mediator Complex Subunit 27 Human Recombinant Protein

PROTQ6P2C8 Regular: 10ug
EUR 380.4
Description: MED27 Human Recombinant produced in E.coli is a single, non-glycosylated polypeptide chain containing 334 amino acids (1-311) and having a molecular mass of 37.8 kDa.;MED27 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

MED20 Mediator Complex Subunit 20 Human Recombinant Protein

PROTQ9H944 Regular: 20ug
EUR 380.4
Description: MED20 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 235 amino acids (1-212 a.a.) and having a molecular mass of 25kDa.;MED20 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

MED21 Mediator Complex Subunit 21 Human Recombinant Protein

PROTQ13503 Regular: 10ug
EUR 380.4
Description: MED21 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 167 amino acids (1-144 a.a.) and having a molecular mass of 18.0kDa.MED21 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

Recombinant Human GP100 (HLA-A*02:01) Complex Protein

RP02686 100μg
EUR 1014

HER2, Active, Human Recombinant

8011-5 each
EUR 288

HER2, Active, Human Recombinant

8011-50 each
EUR 1358.4

MECOM MDS1 And EVI1 Complex Locus Human Recombinant Protein

PROTQ03112 Regular: 10ug
EUR 380.4
Description: MECOM Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 192 amino acids (1-169 a.a) and having a molecular mass of 21.1kDa.

Biotinylated Recombinant Human HLA-G Complex Protein

RP02751 500μg
EUR 487.5

Active Recombinant Human FLT-3/FLK-2/CD135 Protein

RP01314