DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS

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DEFICIENCY OF MYELOID PHD PROTEINS AGGRAVATES ATHEROGENESIS VIA MACROPHAGE APOPTOSIS AND PARACRINE FIBROTIC SIGNALING: Atherogenic results of myeloid PHD knockdown Goals: Atherosclerotic plaque hypoxia is detrimental for macrophage operate. Prolyl hydroxylases (PHDs) provoke mobile hypoxic responses, presumably influencing macrophage operate in plaque hypoxia. Thus, we aimed to elucidate the position of myeloid PHDs in atherosclerosis. Strategies & outcomes: Myeloid […]